Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 63990..64765 Replicon plasmid p2014C-4015-3
Accession NZ_CP034167
Organism Escherichia albertii strain 2014C-4015

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag AYR02_RS24265 Protein ID WP_113650901.1
Coordinates 64283..64765 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag AYR02_RS24260 Protein ID WP_072146426.1
Coordinates 63990..64292 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR02_RS24220 59739..60299 + 561 WP_124783366.1 fertility inhibition protein FinO -
AYR02_RS24225 60502..60664 + 163 Protein_66 transposase -
AYR02_RS24230 60961..61161 + 201 WP_164474008.1 hemolysin expression modulator Hha -
AYR02_RS24235 61404..61760 + 357 WP_059278832.1 hypothetical protein -
AYR02_RS24240 61800..62453 + 654 WP_124783368.1 DNA primase -
AYR02_RS24245 62802..63266 + 465 WP_124783369.1 hypothetical protein -
- 63417..63476 - 60 NuclAT_1 - -
- 63417..63476 - 60 NuclAT_1 - -
- 63417..63476 - 60 NuclAT_1 - -
- 63417..63476 - 60 NuclAT_1 - -
AYR02_RS24255 63521..63670 + 150 WP_072249360.1 type I toxin-antitoxin system Hok family toxin -
AYR02_RS24260 63990..64292 + 303 WP_072146426.1 DUF1778 domain-containing protein Antitoxin
AYR02_RS24265 64283..64765 + 483 WP_113650901.1 GNAT family N-acetyltransferase Toxin
AYR02_RS24270 65077..65334 + 258 WP_059278829.1 replication regulatory protein RepA -
AYR02_RS24280 65565..65639 + 75 WP_001365705.1 RepA leader peptide Tap -
AYR02_RS24285 65632..66489 + 858 WP_124783371.1 incFII family plasmid replication initiator RepA -
AYR02_RS24290 67425..67754 + 330 Protein_77 type II toxin-antitoxin system RelE/ParE family toxin -
AYR02_RS24295 67735..68016 + 282 WP_000780222.1 helix-turn-helix transcriptional regulator -
AYR02_RS24300 68208..68895 + 688 Protein_79 transposase -
AYR02_RS24305 69012..69590 - 579 WP_059236323.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espL2 / vat / papC / papD 1..136645 136645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-146)

Antitoxin

Vibrio phage ICP1, Orf50

(15-99)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17721.53 Da        Isoelectric Point: 7.0386

>T115447 WP_113650901.1 NZ_CP034167:64283-64765 [Escherichia albertii]
MEINVTAPTLLTDEHILQPFDCGNEVLSNWLRGRAMKNQMLNASRTFVICLEGTLRVVGFYSLATGSVTHAELGRTLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVVNLAEQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPDTLFYKV

Download         Length: 483 bp

>T115447 NZ_CP034167:64283-64765 [Escherichia albertii]
ATGGAAATAAATGTCACCGCGCCGACACTGCTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCCCGCACGTTCGTTATTTGTCTGGAGGGTA
CTTTACGTGTTGTGGGGTTCTACTCATTAGCTACGGGTTCCGTCACACATGCCGAGCTTGGGCGCACTTTGCGGCATAAC
ATGCCCAATCCTGTTCCTGTTGTTCTGTTAGGACGTCTGGCTGTCGATGTTTGTACCCAGGGACATGGTTTTGGTAAATG
GCTGCTAAGTGATGCTATTCACCGGGTTGTAAATCTGGCTGAGCAGGTTGGTATTAAGGCTGTTATGGTCCATGCAATTG
ATGATGACGCCAGAGCGTTTTATGAGCGTTTTGGTTTTGTCCAGTCAGTTGTGGCACCCGACACCTTATTTTATAAAGTC
TGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11648.21 Da        Isoelectric Point: 4.7174

>AT115447 WP_072146426.1 NZ_CP034167:63990-64292 [Escherichia albertii]
MEVFMSTAASVRKTPRENQINIRATDEERAVIDYAASLVNKNRTDFIIELAYQEAKNIILDQRLFVLDNERYDSFITQLE
APVQNAEGRERLMAVKPEWK

Download         Length: 303 bp

>AT115447 NZ_CP034167:63990-64292 [Escherichia albertii]
ATGGAGGTTTTTATGTCTACGGCTGCAAGCGTCCGTAAAACACCGCGAGAAAATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACTGATTTCATCATTGAACTGGCTTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGCTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAG
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References