Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3684376..3684994 Replicon chromosome
Accession NZ_CP034166
Organism Escherichia albertii strain 2014C-4015

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag AYR02_RS19065 Protein ID WP_001280991.1
Coordinates 3684376..3684594 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag AYR02_RS19070 Protein ID WP_124783015.1
Coordinates 3684620..3684994 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR02_RS19030 3679665..3680237 + 573 WP_000779847.1 YbaY family lipoprotein -
AYR02_RS19035 3680267..3680578 - 312 WP_000409915.1 MGMT family protein -
AYR02_RS19045 3680959..3681312 + 354 WP_124783013.1 DUF1428 family protein -
AYR02_RS19050 3681350..3682900 - 1551 WP_001260378.1 EAL domain-containing protein -
AYR02_RS19055 3683064..3683534 - 471 WP_124783014.1 YlaC family protein -
AYR02_RS19060 3683642..3684199 - 558 WP_059221620.1 maltose O-acetyltransferase -
AYR02_RS19065 3684376..3684594 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
AYR02_RS19070 3684620..3684994 - 375 WP_124783015.1 Hha toxicity modulator TomB Antitoxin
AYR02_RS19075 3685549..3688698 - 3150 WP_001132500.1 multidrug efflux RND transporter permease subunit -
AYR02_RS19080 3688721..3689914 - 1194 WP_124783016.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T115440 WP_001280991.1 NZ_CP034166:c3684594-3684376 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T115440 NZ_CP034166:c3684594-3684376 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGCTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14423.25 Da        Isoelectric Point: 4.8989

>AT115440 WP_124783015.1 NZ_CP034166:c3684994-3684620 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDESL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT115440 NZ_CP034166:c3684994-3684620 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATCTCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACTAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure

References