Detailed information of TA system TA115430

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 2175192..2175992
• Replicon: chromosome
• Accession: NZ_CP034166
• Organism: Escherichia albertii strain 2014C-4015

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: AYR02_RS11830
• Protein ID: WP_124782623.1
• Coordinates: 2175192..2175719 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: AYR02_RS11835
• Protein ID: WP_124782624.1
• Coordinates: 2175726..2175992 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYR02_RS11805	2170267..2171034	-	768	WP_059278385.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
AYR02_RS11810	2171031..2172308	-	1278	WP_124782621.1	branched chain amino acid ABC transporter permease LivM	-
AYR02_RS11815	2172305..2173231	-	927	WP_001295111.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
AYR02_RS11820	2173279..2174388	-	1110	WP_124782622.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
AYR02_RS11825	2174812..2175195	+	384	Protein_2073	aspartate 1-decarboxylase autocleavage activator PanM	-
AYR02_RS11830	2175192..2175719	-	528	WP_124782623.1	GNAT family N-acetyltransferase	Toxin
AYR02_RS11835	2175726..2175992	-	267	WP_124782624.1	DUF1778 domain-containing protein	Antitoxin
AYR02_RS11840	2176142..2177245	-	1104	WP_124782625.1	branched chain amino acid ABC transporter substrate-binding protein LivJ	-
AYR02_RS11845	2177517..2178371	-	855	WP_000130217.1	RNA polymerase sigma factor RpoH	-
AYR02_RS11850	2178616..2179674	-	1059	WP_001042000.1	permease-like cell division protein FtsX	-
AYR02_RS11855	2179667..2180335	-	669	WP_000617720.1	cell division ATP-binding protein FtsE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (90-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-86)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19524.39 Da
• Isoelectric Point: 6.6303

>T115430 WP_124782623.1 NZ_CP034166:c2175719-2175192 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVCSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Nucleotide

• Length: 528 bp

>T115430 NZ_CP034166:c2175719-2175192 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGCTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9910.31 Da
• Isoelectric Point: 10.0863

>AT115430 WP_124782624.1 NZ_CP034166:c2175992-2175726 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGV

Nucleotide

• Length: 267 bp

>AT115430 NZ_CP034166:c2175992-2175726 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCAGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAGTGTAA