Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1585994..1586645 Replicon chromosome
Accession NZ_CP034166
Organism Escherichia albertii strain 2014C-4015

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag AYR02_RS08880 Protein ID WP_000244763.1
Coordinates 1585994..1586398 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag AYR02_RS08885 Protein ID WP_000354046.1
Coordinates 1586379..1586645 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR02_RS08860 1581952..1583685 - 1734 WP_059221131.1 single-stranded-DNA-specific exonuclease RecJ -
AYR02_RS08865 1583691..1584401 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AYR02_RS08870 1584426..1585322 - 897 WP_124782460.1 site-specific tyrosine recombinase XerD -
AYR02_RS08875 1585434..1585955 + 522 WP_059221135.1 flavodoxin FldB -
AYR02_RS08880 1585994..1586398 - 405 WP_000244763.1 protein YgfX Toxin
AYR02_RS08885 1586379..1586645 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
AYR02_RS08890 1586635..1586865 - 231 WP_000181267.1 hypothetical protein -
AYR02_RS08895 1586897..1587877 + 981 WP_059221136.1 tRNA-modifying protein YgfZ -
AYR02_RS08900 1588079..1588738 - 660 WP_000250281.1 hemolysin III family protein -
AYR02_RS08905 1588906..1589217 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
AYR02_RS08910 1589262..1590695 + 1434 WP_164473993.1 6-phospho-beta-glucosidase BglA -
AYR02_RS08915 1590742..1591627 - 886 Protein_1513 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T115429 WP_000244763.1 NZ_CP034166:c1586398-1585994 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T115429 NZ_CP034166:c1586398-1585994 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT115429 WP_000354046.1 NZ_CP034166:c1586645-1586379 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT115429 NZ_CP034166:c1586645-1586379 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References