Detailed information of TA system TA115414

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 52276..52798
• Replicon: plasmid p2014C-4015-1
• Accession: NZ_CP034165
• Organism: Escherichia albertii strain 2014C-4015

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AYR02_RS00930
• Protein ID: WP_124781968.1
• Coordinates: 52276..52557 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AYR02_RS00935
• Protein ID: WP_124781969.1
• Coordinates: 52547..52798 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYR02_RS00890	47283..47801	+	519	WP_021547912.1	hypothetical protein	-
AYR02_RS00895	48099..48749	+	651	WP_124781959.1	hypothetical protein	-
AYR02_RS00900	48854..49501	+	648	WP_124781961.1	hypothetical protein	-
AYR02_RS00905	49556..49786	+	231	WP_124781963.1	hypothetical protein	-
AYR02_RS00915	50403..50885	-	483	WP_124781964.1	hypothetical protein	-
AYR02_RS00920	51089..51553	-	465	WP_124781966.1	hypothetical protein	-
AYR02_RS00925	51617..52021	-	405	WP_124781967.1	hypothetical protein	-
AYR02_RS00930	52276..52557	-	282	WP_124781968.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AYR02_RS00935	52547..52798	-	252	WP_124781969.1	plasmid stabilization protein	Antitoxin
AYR02_RS00940	53422..53796	-	375	WP_187765141.1	hypothetical protein	-
AYR02_RS00945	53914..54309	-	396	WP_047659410.1	hypothetical protein	-
AYR02_RS00950	54434..54745	-	312	WP_000749407.1	hypothetical protein	-
AYR02_RS00955	54899..55228	-	330	WP_000457357.1	hypothetical protein	-
AYR02_RS00960	56787..56972	-	186	WP_021512335.1	hypothetical protein	-
AYR02_RS00965	57009..57308	-	300	WP_206427752.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..63807	63807

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10963.75 Da
• Isoelectric Point: 10.7513

>T115414 WP_124781968.1 NZ_CP034165:c52557-52276 [Escherichia albertii]
MSYELAFERRALKEWQKLGHTVREQFKKKLSERLKNPRVPAARLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVIAVGK
RESSEVYHTADAR

Nucleotide

• Length: 282 bp

>T115414 NZ_CP034165:c52557-52276 [Escherichia albertii]
ATGAGCTATGAGCTGGCATTTGAACGCAGGGCACTGAAAGAATGGCAGAAGCTCGGCCACACTGTTCGTGAACAATTCAA
AAAGAAGCTGTCAGAGCGCCTGAAAAATCCGCGCGTCCCGGCAGCCAGGCTACATGGTCATACTGACCGTTACAAAATCA
AGCTCCGCGCATCCGGTTACAGACTCGTTTATCAGGTAATTGACGAGAAGGTTGTTTTGCTTGTCATTGCTGTAGGAAAA
AGGGAAAGCAGCGAAGTCTATCACACGGCTGATGCTCGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9251.52 Da
• Isoelectric Point: 4.1322

>AT115414 WP_124781969.1 NZ_CP034165:c52798-52547 [Escherichia albertii]
MSYQILTTTAASITELKKNPMGTVAEGEGEAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKKPDIVKVNL
DEL

Nucleotide

• Length: 252 bp

>AT115414 NZ_CP034165:c52798-52547 [Escherichia albertii]
ATGAGCTATCAAATTCTGACGACGACAGCAGCCAGTATTACTGAGCTGAAAAAAAATCCTATGGGCACTGTAGCGGAAGG
TGAAGGGGAGGCCGTCGCAATCCTGAACCGGAATGAACCCGCGTTTTACTGTGTACCACCAGAACTTTATGCCTACTATC
GGGAACTCGCTGAAGACGCTGAACTTAACGCGATTGCAGATGAAAGAATGAAAAAACCGGACATTGTGAAGGTTAACCTG
GATGAGCTATGA