Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4484398..4485049 Replicon chromosome
Accession NZ_CP034162
Organism Escherichia albertii strain 06-3542

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag CCS91_RS22270 Protein ID WP_000244763.1
Coordinates 4484645..4485049 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CCS91_RS22265 Protein ID WP_000354046.1
Coordinates 4484398..4484664 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCS91_RS22240 4480109..4481542 - 1434 WP_059221179.1 6-phospho-beta-glucosidase BglA -
CCS91_RS22245 4481587..4481898 + 312 WP_124866677.1 N(4)-acetylcytidine aminohydrolase -
CCS91_RS22250 4482066..4482725 + 660 WP_000250281.1 hemolysin III family protein -
CCS91_RS22255 4483166..4484146 - 981 WP_059221136.1 tRNA-modifying protein YgfZ -
CCS91_RS22260 4484178..4484408 + 231 WP_000181267.1 hypothetical protein -
CCS91_RS22265 4484398..4484664 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CCS91_RS22270 4484645..4485049 + 405 WP_000244763.1 protein YgfX Toxin
CCS91_RS22275 4485083..4485604 - 522 WP_059221135.1 flavodoxin FldB -
CCS91_RS22280 4485716..4486612 + 897 WP_124866678.1 site-specific tyrosine recombinase XerD -
CCS91_RS22285 4486637..4487347 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CCS91_RS22290 4487353..4489086 + 1734 WP_059221131.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T115410 WP_000244763.1 NZ_CP034162:4484645-4485049 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T115410 NZ_CP034162:4484645-4485049 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT115410 WP_000354046.1 NZ_CP034162:4484398-4484664 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT115410 NZ_CP034162:4484398-4484664 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References