Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 479892..480533 Replicon plasmid pPagL15_1
Accession NZ_CP034149
Organism Pantoea agglomerans strain L15

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CBF16_RS21410 Protein ID WP_124890676.1
Coordinates 479892..480074 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CBF16_RS21415 Protein ID WP_124890677.1
Coordinates 480120..480533 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBF16_RS21365 475112..475309 - 198 Protein_455 DUF826 domain-containing protein -
CBF16_RS21370 475409..476026 - 618 WP_124890670.1 hypothetical protein -
CBF16_RS21375 476010..476840 - 831 WP_124890756.1 hypothetical protein -
CBF16_RS21380 476870..477406 - 537 WP_124890671.1 hypothetical protein -
CBF16_RS21385 477444..477638 - 195 WP_124890757.1 Rz1 family lipoprotein -
CBF16_RS23090 477670..477840 + 171 WP_164480421.1 hypothetical protein -
CBF16_RS21390 477888..478307 - 420 WP_124890672.1 structural protein -
CBF16_RS21395 478294..478584 - 291 WP_124890673.1 phage holin family protein -
CBF16_RS21400 478584..478952 - 369 WP_124890674.1 hypothetical protein -
CBF16_RS21405 479176..479481 + 306 WP_124890675.1 hypothetical protein -
CBF16_RS21410 479892..480074 + 183 WP_124890676.1 type II toxin-antitoxin system HicA family toxin Toxin
CBF16_RS21415 480120..480533 + 414 WP_124890677.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CBF16_RS21420 481255..481560 - 306 WP_124890678.1 hypothetical protein -
CBF16_RS21425 481968..483953 - 1986 WP_164480422.1 ATP-binding protein -
CBF16_RS21430 483943..484986 - 1044 WP_124890680.1 DNA cytosine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..583567 583567


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6889.01 Da        Isoelectric Point: 10.6217

>T115382 WP_124890676.1 NZ_CP034149:479892-480074 [Pantoea agglomerans]
MKSSELIKLLEKNGWQLDRVKGSHHQFSHPDFTNIVTVPHPKKDLKTGTAHQIMKDAKLK

Download         Length: 183 bp

>T115382 NZ_CP034149:479892-480074 [Pantoea agglomerans]
TTGAAGAGTTCGGAACTGATAAAGCTGTTAGAGAAAAATGGCTGGCAACTAGACAGAGTGAAAGGAAGTCATCACCAGTT
CAGCCACCCGGATTTCACTAACATAGTAACGGTTCCGCACCCTAAGAAAGATTTGAAGACTGGTACAGCTCACCAAATCA
TGAAGGATGCGAAACTTAAATAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15185.17 Da        Isoelectric Point: 4.5641

>AT115382 WP_124890677.1 NZ_CP034149:480120-480533 [Pantoea agglomerans]
MLYYGVVEIDHDKTASGYFPGITGCIFAGDNMREALQDAESALNAHFELMAEKGLSIPEANDIPDIDSGDYGESGLKVVM
ICVDIDITKYLGKSERINITMPHLLIEKIDRAVGQDSRYTSRSQFIAEAARKELSHR

Download         Length: 414 bp

>AT115382 NZ_CP034149:480120-480533 [Pantoea agglomerans]
ATGTTGTATTACGGCGTCGTTGAAATCGACCACGACAAAACAGCCAGCGGTTACTTTCCCGGCATTACCGGCTGTATTTT
CGCTGGCGATAATATGCGAGAAGCACTGCAGGATGCCGAGTCGGCGCTTAACGCTCACTTTGAGCTGATGGCCGAAAAGG
GTCTTTCCATTCCTGAAGCGAATGATATACCCGATATCGATTCAGGTGATTACGGTGAGAGTGGCCTGAAGGTGGTGATG
ATCTGCGTTGATATCGATATCACCAAATATCTCGGCAAGTCAGAGAGGATCAACATCACCATGCCGCATCTGCTGATTGA
GAAGATCGACAGGGCTGTGGGACAGGACTCCCGCTATACCAGCCGCAGCCAGTTTATTGCAGAAGCTGCACGCAAAGAGC
TGTCTCATCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References