Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1987605..1989166 Replicon chromosome
Accession NZ_CP034148
Organism Pantoea agglomerans strain L15

Toxin (Protein)


Gene name hipA Uniprot ID A0A8X8J3D8
Locus tag CBF16_RS09505 Protein ID WP_022625645.1
Coordinates 1987605..1988918 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CBF16_RS09510 Protein ID WP_010244879.1
Coordinates 1988918..1989166 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBF16_RS09485 1982858..1983193 + 336 WP_010670154.1 gamma-glutamylcyclotransferase -
CBF16_RS09490 1983580..1985625 - 2046 WP_010244891.1 FUSC family protein -
CBF16_RS09495 1985701..1987122 - 1422 WP_124889970.1 M24 family metallopeptidase -
CBF16_RS09500 1987294..1987500 - 207 WP_010244885.1 type II toxin-antitoxin system MqsA family antitoxin -
CBF16_RS09505 1987605..1988918 - 1314 WP_022625645.1 type II toxin-antitoxin system HipA family toxin Toxin
CBF16_RS09510 1988918..1989166 - 249 WP_010244879.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
CBF16_RS09515 1989347..1989784 + 438 WP_124889971.1 GNAT family N-acetyltransferase -
CBF16_RS09520 1989818..1990612 - 795 WP_124889972.1 inositol monophosphatase -
CBF16_RS09525 1990636..1991697 - 1062 WP_010244870.1 ABC transporter ATP-binding protein -
CBF16_RS09530 1991694..1993919 - 2226 WP_124889973.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-54)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49147.73 Da        Isoelectric Point: 8.4280

>T115377 WP_022625645.1 NZ_CP034148:c1988918-1987605 [Pantoea agglomerans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSMPLQVKALTSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDETRLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTDEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGQMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFIKAFP
QAVVSVRDALPPDFPQHIADAIFSHSLIMLERLRHKE

Download         Length: 1314 bp

>T115377 NZ_CP034148:c1988918-1987605 [Pantoea agglomerans]
ATGCAAAGGCTGATTGCGTGGATGAACGGCGAGCGGGTAGGCGTACTCACCCGCCAGCGAAACGGCGCTCATGAGTTTCA
GTATGATACCGGCTGGCTGAGTAATCCGCTCTCCAGGCCGCTGTCACTCTCCATGCCGTTGCAGGTTAAGGCTCTCACCT
CACACGCCGTGATTAACTTCTTCGATAACCTGCTGCCGGATAGCCCATTGATTCGCGACAGAATCGTGGCGCGTTACCAG
ATTAAATCCCGTCAGCCCTTTGATCTGTTGCAGGAAGTGGGACGTGACAGCGTCGGGGCGACTATGCTGCTGCCGCCCGA
TATGCCACTGCCCGCACTGCAGGCCCGCTATGAAGTGCTGGATGAAACCCGGCTCGAAAGCGTGCTGTCGGCCTATCAGT
CAGATATCCCGCTGGGGATGCTGCGTGAAGAGACCGATTTCCGTATCTCGGTCGCAGGGGCGCAGGAGAAAACCGCACTG
CTGCTGACCGATGAAGGCTGGAGCATTCCTGCCGGTGCCACGCCCACCTCGCACATCATTAAGCTGCCGATCGGAGAGAT
TAAACAGCCGGCCGCGACGCTGGATATGCGTGAAAGTGTGGAGAATGAGTATCTCTGTCTGGCGCTGGCCCGTGCACTCG
GTATCGACGTGCCGCAGGCAACGATTATCCGTGCCGGACAGATGCGCGCCCTGGCGGTAGAACGTTTCGACCGCCGCTGG
TCACGCGATAAAACCCGGTTGATTCGCCTGCCGCAGGAGGATTTCTGTCAGGCGCTGGGACTGCCATCTTCAACCAAATA
TGAGTCGGATGGCGGGCCAGGCATTGCGGAGATCATGCAGATACTGATGGGATCGAGCAACGCCATCGAAGATCGCTATC
GCTTTATGATGTTCCAGGTGTTTCAGTGGCTGATTGGCGCAACCGACGGTCACGCCAAGAACTTCTCACTGTTTATTGAG
CGCGGCGGCAGTTATCGACTGACTCCCTTTTATGATGTGATCTCCGCTTATCCGGTACTGGGCGGCACCGGTCTGAACAA
GCGAGCGCTGAAACTGGCGATGGGTCTGCGTGCCACTAAGGGGAAGAAGACAGAGATCGACAAAATCTTCCCGCGCCATT
TTATCGCCACGGCAAAAAGCGTCAGTTTTGATCGTGACAGTTTGCAGCAGATCTTCGACTTCTTTATTAAGGCCTTTCCC
CAGGCAGTGGTCTCGGTGCGCGATGCCTTGCCGCCCGATTTCCCGCAGCACATCGCCGACGCCATCTTCAGTCACTCACT
CATTATGCTGGAGCGGCTGCGGCACAAAGAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9333.58 Da        Isoelectric Point: 5.0775

>AT115377 WP_010244879.1 NZ_CP034148:c1989166-1988918 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQSLELSLEVQEKEEAGAPQLHDED
EW

Download         Length: 249 bp

>AT115377 NZ_CP034148:c1989166-1988918 [Pantoea agglomerans]
ATGATATACAGCCCGCTACAGCTGGCAAACCGGCTAAAGCTCATTCGTCAGCGTAATGGCTGGACCCAAAGTGAGCTGGC
GAAAAAGGTCGGCCTGAAACAGGCCACCATCTCTCACTTTGAAAATGCCCCTGACAGTACCTCGCTGGCAACGCTGTTTA
AGCTGTTACAGTCGCTGGAGCTGAGTCTGGAAGTTCAGGAGAAAGAGGAGGCCGGTGCGCCTCAGCTGCATGATGAGGAT
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References