Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1722182..1722766 Replicon chromosome
Accession NZ_CP034148
Organism Pantoea agglomerans strain L15

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CBF16_RS08200 Protein ID WP_010245793.1
Coordinates 1722182..1722517 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CBF16_RS08205 Protein ID WP_010245791.1
Coordinates 1722518..1722766 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBF16_RS08185 1717427..1720045 + 2619 WP_124889913.1 nitrate reductase -
CBF16_RS08190 1720045..1720884 + 840 WP_124890443.1 uroporphyrinogen-III C-methyltransferase -
CBF16_RS08195 1721494..1721880 - 387 WP_022625774.1 hypothetical protein -
CBF16_RS08200 1722182..1722517 - 336 WP_010245793.1 endoribonuclease MazF Toxin
CBF16_RS08205 1722518..1722766 - 249 WP_010245791.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
CBF16_RS08210 1722923..1723735 - 813 WP_010245789.1 DeoR/GlpR family DNA-binding transcription regulator -
CBF16_RS08215 1724088..1724885 + 798 WP_124889914.1 D-threitol dehydrogenase -
CBF16_RS08220 1724941..1725876 + 936 WP_124889915.1 D-ribose ABC transporter substrate-binding protein -
CBF16_RS08225 1725922..1726533 + 612 WP_124890444.1 DUF2291 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-111)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12038.05 Da        Isoelectric Point: 9.2246

>T115375 WP_010245793.1 NZ_CP034148:c1722517-1722182 [Pantoea agglomerans]
MVSRFVPDAGDIIWVDFDPTKGSEQAGHRPAIVLSPFAYNNKTGMCLCVPCTTMSKGYPFEVPISAEKESVALSDQVKSI
AWKVRGATKKGVVSANELQQIRAKIKVIIGL

Download         Length: 336 bp

>T115375 NZ_CP034148:c1722517-1722182 [Pantoea agglomerans]
ATGGTAAGCCGTTTTGTCCCTGATGCGGGAGATATCATCTGGGTGGATTTTGATCCGACCAAAGGCAGTGAGCAGGCAGG
TCACAGACCCGCTATTGTTCTTAGCCCGTTTGCTTACAATAACAAGACCGGCATGTGTCTCTGTGTCCCCTGCACCACCA
TGTCAAAGGGCTATCCGTTTGAAGTCCCCATTAGTGCTGAAAAAGAAAGCGTCGCATTATCCGATCAAGTGAAAAGCATC
GCCTGGAAAGTCAGGGGAGCAACCAAAAAAGGCGTTGTTTCCGCAAACGAACTTCAGCAAATTCGCGCTAAGATAAAAGT
TATCATTGGCTTATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9271.61 Da        Isoelectric Point: 4.1826

>AT115375 WP_010245791.1 NZ_CP034148:c1722766-1722518 [Pantoea agglomerans]
MIHGNVKRWGNSPAIRIPATLMQALNLNIDDEIKIDLVEGKLIIEPVKQEVGYSLEELLEGVTEENLHDPVEWGEPVGKE
IW

Download         Length: 249 bp

>AT115375 NZ_CP034148:c1722766-1722518 [Pantoea agglomerans]
ATGATTCATGGAAATGTTAAACGCTGGGGTAACTCTCCGGCGATACGTATCCCGGCGACATTGATGCAGGCACTAAATCT
TAATATTGATGACGAAATTAAAATCGATTTAGTTGAAGGGAAACTCATTATCGAGCCTGTCAAACAGGAAGTGGGTTACT
CTCTTGAAGAACTGCTTGAAGGCGTGACAGAGGAAAATCTGCACGATCCAGTCGAATGGGGTGAACCTGTCGGGAAGGAG
ATTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References