Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1027191..1027737 Replicon chromosome
Accession NZ_CP034147
Organism Helicobacter pylori strain HP14039

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EAL91_RS05090 Protein ID WP_121054522.1
Coordinates 1027492..1027737 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EAL91_RS05085 Protein ID WP_121054521.1
Coordinates 1027191..1027478 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAL91_RS05060 1022224..1023336 + 1113 WP_121054519.1 hydrogenase formation protein HypD -
EAL91_RS05065 1023287..1023933 - 647 Protein_941 hypothetical protein -
EAL91_RS05080 1024309..1026525 + 2217 WP_121054520.1 outer membrane beta-barrel protein -
EAL91_RS05085 1027191..1027478 + 288 WP_121054521.1 hypothetical protein Antitoxin
EAL91_RS05090 1027492..1027737 + 246 WP_121054522.1 YafQ family addiction module toxin Toxin
EAL91_RS05095 1027682..1027833 + 152 Protein_945 virulence protein -
EAL91_RS05100 1028044..1028568 - 525 WP_001135624.1 acyl-CoA thioesterase -
EAL91_RS05105 1028708..1029562 + 855 WP_121054523.1 SDR family oxidoreductase -
EAL91_RS05110 1029555..1030535 + 981 WP_000921461.1 iron ABC transporter permease -
EAL91_RS05115 1030535..1031302 + 768 WP_121054524.1 ABC transporter ATP-binding protein -
EAL91_RS05120 1031380..1032486 + 1107 WP_207208546.1 glycosyltransferase family 8 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9361.19 Da        Isoelectric Point: 10.2440

>T115370 WP_121054522.1 NZ_CP034147:1027492-1027737 [Helicobacter pylori]
MLIIETSKKFDKDLEILVKNGFDLKLLYKVVGNLAKEQPLAPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKRKHSSAS
L

Download         Length: 246 bp

>T115370 NZ_CP034147:1027492-1027737 [Helicobacter pylori]
ATGCTGATAATTGAAACCAGTAAAAAATTTGATAAGGATCTTGAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
GTATAAAGTGGTTGGAAATTTAGCCAAAGAGCAACCCCTAGCTCCCAAATACAAAGACCACCCACTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAAAGAAAACACTCTAGCGCAAGT
CTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11418.20 Da        Isoelectric Point: 10.2670

>AT115370 WP_121054521.1 NZ_CP034147:1027191-1027478 [Helicobacter pylori]
MPNTTNKDYTKYSQRQLFNLLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKVLNLTENGYTIEEEREILARAKDTKNHF
CFKSIEDFKKYCENL

Download         Length: 288 bp

>AT115370 NZ_CP034147:1027191-1027478 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCCAAAGACAGCTTTTTAATCTTTTAAATTCTATCAAAACCAA
GCAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAGCAAAGGATTAAAAAAGCGCTCCAATTTAAAGTGC
TAAACCTAACCGAAAATGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAGGACACTAAGAACCACTTT
TGTTTTAAAAGCATAGAGGATTTTAAGAAGTATTGTGAAAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References