Detailed information of TA system TA115369

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 4413554..4414101
• Replicon: chromosome
• Accession: NZ_CP034142
• Organism: Marinobacter sp. NP-4(2019)

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EHN06_RS20080
• Protein ID: WP_127334238.1
• Coordinates: 4413554..4413856 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U7NTA2
• Locus tag: EHN06_RS20085
• Protein ID: WP_022992576.1
• Coordinates: 4413844..4414101 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHN06_RS20040	4408772..4409575	-	804	WP_206075671.1	IS3 family transposase	-
EHN06_RS20045	4409581..4409952	-	372	WP_127332884.1	transposase	-
EHN06_RS20050	4410038..4410385	-	348	WP_022993294.1	DUF3024 domain-containing protein	-
EHN06_RS20055	4410487..4411116	-	630	WP_127334234.1	peptidase M15	-
EHN06_RS20060	4411198..4411830	-	633	WP_127334235.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
EHN06_RS20065	4411938..4412528	-	591	WP_206075697.1	hypothetical protein	-
EHN06_RS20070	4412610..4413002	-	393	WP_127334236.1	hypothetical protein	-
EHN06_RS20075	4413088..4413468	-	381	WP_127334237.1	hypothetical protein	-
EHN06_RS20080	4413554..4413856	-	303	WP_127334238.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHN06_RS20085	4413844..4414101	-	258	WP_022992576.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EHN06_RS20090	4414231..4414539	-	309	WP_127334239.1	hypothetical protein	-
EHN06_RS20095	4414616..4415083	-	468	WP_127334240.1	hypothetical protein	-
EHN06_RS20100	4415237..4415560	+	324	WP_127334241.1	hypothetical protein	-
EHN06_RS20105	4415651..4416031	-	381	WP_127334242.1	phosphopantetheine adenylyltransferase	-
EHN06_RS20110	4416150..4416560	-	411	WP_127334533.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
EHN06_RS20115	4416693..4417142	-	450	WP_127334243.1	SMI1/KNR4 family protein	-
EHN06_RS20120	4417362..4418327	+	966	WP_127334244.1	integron integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4408321..4423544	15223
	-	inside	Integron	-	-	4410038..4418327	8289

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11679.36 Da
• Isoelectric Point: 4.2900

>T115369 WP_127334238.1 NZ_CP034142:c4413856-4413554 [Marinobacter sp. NP-4(2019)]
MAEVIWTEPALQELDAIAEYIALDNPVAASHLVQEVFDKTERLEDFPQSGRIPPELPDSVYREVVIPPCRIFYREDEKRV
LVLYVMREERQLRAYMLGNS

Nucleotide

• Length: 303 bp

>T115369 NZ_CP034142:c4413856-4413554 [Marinobacter sp. NP-4(2019)]
ATGGCTGAAGTAATCTGGACGGAGCCTGCCCTTCAAGAACTGGATGCCATCGCTGAGTACATTGCTCTGGATAATCCTGT
TGCCGCAAGTCATCTGGTCCAAGAAGTTTTCGATAAGACCGAGCGCTTGGAAGATTTTCCCCAATCCGGACGGATTCCTC
CAGAGCTCCCTGATTCGGTATACAGGGAGGTAGTGATTCCACCGTGTCGCATTTTTTATCGTGAGGATGAGAAGCGGGTT
CTCGTCCTCTATGTCATGCGAGAGGAGCGGCAGCTTCGTGCATACATGCTTGGGAACAGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9901.44 Da
• Isoelectric Point: 8.5042

>AT115369 WP_022992576.1 NZ_CP034142:c4414101-4413844 [Marinobacter sp. NP-4(2019)]
MKVELVTNLKRQATKILADLHLSKEPILITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQSEAREKM
SKWLK

Nucleotide

• Length: 258 bp

>AT115369 NZ_CP034142:c4414101-4413844 [Marinobacter sp. NP-4(2019)]
ATGAAAGTTGAGCTTGTTACGAACCTCAAGCGCCAAGCCACAAAGATTCTGGCAGATCTGCACTTGTCTAAAGAGCCGAT
ACTGATAACGGAGCATGGTCAGCCATCCGCATACCTTGTCGATGTGCAGGATTACGAGTTTATGCAGCGCCGACTTGAGC
TGCTTGAGGGGCTCTCACGGGGAGAGCGTGCTGTACTTGAGGGAAGAACGTACAGCCAAAGTGAGGCCAGGGAGAAAATG
AGTAAATGGCTGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A455VBQ8