Detailed information of TA system TA115365

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 390833..391335
• Replicon: chromosome
• Accession: NZ_CP034142
• Organism: Marinobacter sp. NP-4(2019)

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: EHN06_RS01710
• Protein ID: WP_127329598.1
• Coordinates: 390833..391087 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EHN06_RS01715
• Protein ID: WP_127329600.1
• Coordinates: 391084..391335 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHN06_RS01685	385926..387257	+	1332	WP_127329590.1	cobyrinate a,c-diamide synthase	-
EHN06_RS01690	387250..387861	+	612	WP_127329592.1	cob(I)yrinic acid a,c-diamide adenosyltransferase	-
EHN06_RS01695	387875..389389	+	1515	WP_127329594.1	cobyric acid synthase	-
EHN06_RS01700	389430..390149	+	720	WP_127329596.1	5,6-dimethylbenzimidazole synthase	-
EHN06_RS01705	390159..390344	-	186	Protein_336	phage integrase N-terminal SAM-like domain-containing protein	-
EHN06_RS01710	390833..391087	-	255	WP_127329598.1	Txe/YoeB family addiction module toxin	Toxin
EHN06_RS01715	391084..391335	-	252	WP_127329600.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EHN06_RS01720	391493..391950	+	458	Protein_339	transposase	-
EHN06_RS01725	392219..392659	+	441	WP_127329602.1	GNAT family N-acetyltransferase	-
EHN06_RS01730	392782..393153	+	372	WP_206075709.1	VOC family protein	-
EHN06_RS01735	393214..393849	+	636	WP_127329604.1	glutathione S-transferase family protein	-
EHN06_RS01740	394000..394602	-	603	WP_127329606.1	GNAT family N-acetyltransferase	-
EHN06_RS01745	394679..395596	-	918	WP_127329608.1	LysR family transcriptional regulator	-
EHN06_RS01750	395713..396312	+	600	WP_127334315.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10270.85 Da
• Isoelectric Point: 9.8162

>T115365 WP_127329598.1 NZ_CP034142:c391087-390833 [Marinobacter sp. NP-4(2019)]
MKLIFSENTWEDYLYWQKTDKKILNRINKLIKETKREPFEGVGKPEPLKHSLAGYWSRRINDEHRMVYKVTDDALLIAQL
RYHY

Nucleotide

• Length: 255 bp

>T115365 NZ_CP034142:c391087-390833 [Marinobacter sp. NP-4(2019)]
ATGAAACTCATCTTCTCCGAGAACACCTGGGAAGACTATCTGTACTGGCAAAAAACCGACAAAAAGATCCTTAACCGAAT
CAACAAGCTGATCAAAGAGACCAAGCGAGAACCGTTCGAAGGTGTTGGTAAACCAGAACCCCTCAAGCACAGCCTGGCCG
GCTACTGGTCCCGGCGAATCAATGATGAACACCGAATGGTGTACAAAGTCACGGATGACGCTTTGCTTATCGCCCAGCTC
CGGTATCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9238.48 Da
• Isoelectric Point: 4.4750

>AT115365 WP_127329600.1 NZ_CP034142:c391335-391084 [Marinobacter sp. NP-4(2019)]
MDAISYTAARTNLAKTMEQVCEDHSPVIITRSKSPSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE

Nucleotide

• Length: 252 bp

>AT115365 NZ_CP034142:c391335-391084 [Marinobacter sp. NP-4(2019)]
ATGGATGCCATTAGCTACACAGCCGCTAGAACCAATCTAGCAAAAACCATGGAGCAGGTCTGTGAAGACCATTCCCCTGT
GATCATCACCCGGAGCAAGTCGCCGTCAGTGGTAATGATCTCCCTGGAGGACTACGAGGCGCTGCAAGAAACTGCATACC
TTCTGCGCGCACCAAAAAACGCACGGCGTTTGCTGGAATCCGTTGCCGAGCTGGAGCAAGGCGGCGGTCAAGAAAAGGAA
CTTCTTGAATGA