Detailed information of TA system TA115359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4836389..4836902
• Replicon: chromosome
• Accession: NZ_CP034136
• Organism: Klebsiella quasipneumoniae subsp. similipneumoniae strain G747

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BME36_RS24490
• Protein ID: WP_064190102.1
• Coordinates: 4836389..4836670 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: BME36_RS24495
• Protein ID: WP_002886901.1
• Coordinates: 4836660..4836902 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BME36_RS24475	4831431..4833086	+	1656	WP_048322789.1	alpha,alpha-phosphotrehalase	-
BME36_RS24480	4833472..4835610	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
BME36_RS24485	4835921..4836385	+	465	WP_064190101.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
BME36_RS24490	4836389..4836670	-	282	WP_064190102.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BME36_RS24495	4836660..4836902	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BME36_RS24500	4836980..4838890	-	1911	WP_087812468.1	BglG family transcription antiterminator	-
BME36_RS24505	4838913..4840067	-	1155	WP_064190103.1	lactonase family protein	-
BME36_RS24510	4840230..4840970	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11031.81 Da
• Isoelectric Point: 10.1752

>T115359 WP_064190102.1 NZ_CP034136:c4836670-4836389 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNNLQQIMQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T115359 NZ_CP034136:c4836670-4836389 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAATCTCCAGCAGATTATGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT115359 WP_002886901.1 NZ_CP034136:c4836902-4836660 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT115359 NZ_CP034136:c4836902-4836660 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGTCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0