Detailed information of TA system TA115347

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 820169..820826
• Replicon: chromosome
• Accession: NZ_CP034136
• Organism: Klebsiella quasipneumoniae subsp. similipneumoniae strain G747

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8G2AFI7
• Locus tag: BME36_RS04195
• Protein ID: WP_064190060.1
• Coordinates: 820416..820826 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: BME36_RS04190
• Protein ID: WP_002916312.1
• Coordinates: 820169..820435 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BME36_RS04165	815326..816759	-	1434	WP_004205314.1	6-phospho-beta-glucosidase BglA	-
BME36_RS04170	816878..817606	-	729	WP_004205316.1	MurR/RpiR family transcriptional regulator	-
BME36_RS04175	817656..817967	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
BME36_RS04180	818130..818789	+	660	WP_064190059.1	hemolysin III family protein	-
BME36_RS04185	818940..819923	-	984	WP_017899798.1	tRNA-modifying protein YgfZ	-
BME36_RS04190	820169..820435	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
BME36_RS04195	820416..820826	+	411	WP_064190060.1	protein YgfX	Toxin
BME36_RS04200	820833..821354	-	522	WP_004205324.1	flavodoxin FldB	-
BME36_RS04205	821455..822351	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
BME36_RS04210	822374..823087	+	714	WP_004205326.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
BME36_RS04215	823093..824826	+	1734	WP_004205327.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16065.85 Da
• Isoelectric Point: 11.4778

>T115347 WP_064190060.1 NZ_CP034136:820416-820826 [Klebsiella quasipneumoniae subsp. similipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRSQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T115347 NZ_CP034136:820416-820826 [Klebsiella quasipneumoniae subsp. similipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGCGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGAATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCAG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT115347 WP_002916312.1 NZ_CP034136:820169-820435 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT115347 NZ_CP034136:820169-820435 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGAATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41