Detailed information of TA system TA115341

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 4825295..4825998
• Replicon: chromosome
• Accession: NZ_CP034129
• Organism: Klebsiella quasipneumoniae strain G4584

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: BME54_RS24545
• Protein ID: WP_064190208.1
• Coordinates: 4825295..4825636 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A2Z3WZC0
• Locus tag: BME54_RS24550
• Protein ID: WP_032410777.1
• Coordinates: 4825657..4825998 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BME54_RS24530	4822028..4822666	-	639	WP_064190206.1	HNH endonuclease	-
BME54_RS24535	4822846..4823715	+	870	WP_064190207.1	HNH endonuclease	-
BME54_RS24540	4824033..4825040	-	1008	WP_004108748.1	restriction endonuclease	-
BME54_RS24545	4825295..4825636	-	342	WP_064190208.1	TA system toxin CbtA family protein	Toxin
BME54_RS24550	4825657..4825998	-	342	WP_032410777.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
BME54_RS24555	4826009..4826551	-	543	WP_064190209.1	DNA repair protein RadC	-
BME54_RS24560	4826564..4827006	-	443	Protein_4729	antirestriction protein	-
BME54_RS24565	4827037..4827858	-	822	WP_064190210.1	DUF945 domain-containing protein	-
BME54_RS24570	4827978..4828451	-	474	WP_064190211.1	hypothetical protein	-
BME54_RS24575	4828523..4828975	-	453	WP_077268172.1	hypothetical protein	-
BME54_RS24580	4829011..4829727	-	717	WP_064190213.1	WYL domain-containing protein	-
BME54_RS24585	4829971..4830846	-	876	WP_064190214.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4825295..4840356	15061

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-111)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12709.70 Da
• Isoelectric Point: 8.5104

>T115341 WP_064190208.1 NZ_CP034129:c4825636-4825295 [Klebsiella quasipneumoniae]
MKTLPATTPQAAKLCLSPVSVWQMLLACLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Nucleotide

• Length: 342 bp

>T115341 NZ_CP034129:c4825636-4825295 [Klebsiella quasipneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGAAGCTATGTCTGTCGCCCGTGTCTGTCTGGCAAATGCTGCTTGC
ATGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACGCCGTTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12765.40 Da
• Isoelectric Point: 7.0269

>AT115341 WP_032410777.1 NZ_CP034129:c4825998-4825657 [Klebsiella quasipneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHRVTLYHNGFTCEADTLGSCGYVYIAVYSTHR

Nucleotide

• Length: 342 bp

>AT115341 NZ_CP034129:c4825998-4825657 [Klebsiella quasipneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTAAAATGGGGACTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACCGCGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACTCCACCCATCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2Z3WZC0