Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3451546..3452134 Replicon chromosome
Accession NZ_CP034122
Organism Caulobacter vibrioides strain CB2A

Toxin (Protein)


Gene name hicA Uniprot ID Q9A3L9
Locus tag EIB18_RS16870 Protein ID WP_010921020.1
Coordinates 3451546..3451734 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q9A3L8
Locus tag EIB18_RS16875 Protein ID WP_010921021.1
Coordinates 3451739..3452134 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIB18_RS16845 3447429..3448448 - 1020 WP_096034295.1 amidohydrolase family protein -
EIB18_RS16850 3448624..3449659 + 1036 Protein_3260 adenosine deaminase -
EIB18_RS16855 3449670..3450638 + 969 WP_096034299.1 magnesium and cobalt transport protein CorA -
EIB18_RS16860 3450616..3451167 - 552 WP_096034300.1 transporter -
EIB18_RS16865 3451164..3451469 - 306 WP_010921019.1 PadR family transcriptional regulator -
EIB18_RS16870 3451546..3451734 + 189 WP_010921020.1 type II toxin-antitoxin system HicA family toxin Toxin
EIB18_RS16875 3451739..3452134 + 396 WP_010921021.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EIB18_RS16880 3452143..3452619 - 477 WP_096034301.1 DUF2199 domain-containing protein -
EIB18_RS16885 3452677..3453675 - 999 WP_096034302.1 DegT/DnrJ/EryC1/StrS aminotransferase family protein -
EIB18_RS16890 3453803..3455356 - 1554 WP_096034303.1 acyl--CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6984.02 Da        Isoelectric Point: 11.4778

>T115299 WP_010921020.1 NZ_CP034122:3451546-3451734 [Caulobacter vibrioides]
MNSREVIAALEADGWVEVARRGSHAQFKHPTKSGRVTVPHPKRDLPLGTLRSIERQADLKLR

Download         Length: 189 bp

>T115299 NZ_CP034122:3451546-3451734 [Caulobacter vibrioides]
ATGAACAGTCGTGAGGTGATCGCGGCGCTGGAAGCCGATGGCTGGGTCGAAGTCGCACGGCGCGGTTCTCATGCGCAGTT
CAAGCACCCGACCAAGTCCGGGCGCGTGACCGTGCCGCACCCCAAGCGCGACTTGCCGCTGGGAACCCTGCGCTCGATCG
AGCGTCAGGCCGACCTGAAACTGAGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 13937.84 Da        Isoelectric Point: 4.1587

>AT115299 WP_010921021.1 NZ_CP034122:3451739-3452134 [Caulobacter vibrioides]
MADYIALIHKDADSAFGVSFPDLPGCISVGETLEEARANAEEALALHVEGMIEDGETLPAPSALDEVMAAPGNRDGVVIL
VPLKTVQPRTVRVNITLPETTLREIDAFAETYGYTRSGLLARAAKQMIDAA

Download         Length: 396 bp

>AT115299 NZ_CP034122:3451739-3452134 [Caulobacter vibrioides]
ATGGCCGACTATATCGCCCTGATCCACAAGGACGCCGACAGCGCCTTCGGCGTATCTTTTCCCGACCTGCCCGGCTGTAT
CAGCGTCGGCGAGACGCTGGAAGAAGCCCGCGCCAACGCCGAGGAGGCCCTGGCGCTGCATGTCGAGGGCATGATCGAGG
ATGGCGAAACCCTGCCGGCGCCGTCCGCCCTGGACGAAGTCATGGCAGCCCCCGGCAACCGCGACGGTGTGGTGATCCTT
GTGCCGCTGAAGACCGTCCAGCCTCGGACGGTGCGGGTCAATATCACCTTACCCGAGACCACACTGCGCGAGATCGACGC
CTTCGCCGAAACCTATGGCTACACGCGTTCGGGTCTGCTGGCCCGCGCCGCCAAGCAGATGATCGACGCTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A290MM32

Antitoxin

Source ID Structure
AlphaFold DB Q9A3L8

References