Detailed information of TA system TA115298

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 3391678..3392120
• Replicon: chromosome
• Accession: NZ_CP034122
• Organism: Caulobacter vibrioides strain CB2A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EIB18_RS16595
• Protein ID: WP_205685753.1
• Coordinates: 3391845..3392120 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: P0CW75
• Locus tag: EIB18_RS16590
• Protein ID: WP_012640671.1
• Coordinates: 3391678..3391857 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIB18_RS16575	3386736..3388757	-	2022	WP_096034260.1	tetratricopeptide repeat-containing sulfotransferase family protein	-
EIB18_RS16580	3388840..3390129	-	1290	WP_096034261.1	FAD-binding oxidoreductase	-
EIB18_RS16585	3390205..3391602	-	1398	WP_010920966.1	glutamine synthetase family protein	-
EIB18_RS16590	3391678..3391857	+	180	WP_012640671.1	antitoxin RelB4	Antitoxin
EIB18_RS16595	3391845..3392120	+	276	WP_205685753.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EIB18_RS16600	3392123..3393526	-	1404	WP_096034263.1	aspartate aminotransferase family protein	-
EIB18_RS16605	3393544..3394272	-	729	WP_124743095.1	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	-
EIB18_RS16610	3394453..3395595	-	1143	Protein_3214	ABC transporter ATP-binding protein	-
EIB18_RS16615	3395758..3396617	-	860	Protein_3215	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10141.74 Da
• Isoelectric Point: 11.9574

>T115298 WP_205685753.1 NZ_CP034122:3391845-3392120 [Caulobacter vibrioides]
VAQVVWTQRAMADVYAIVGHISEQSRPLAAQRLAKRLFDTGASLATYPERGRVSTQGRREIVAISPYVLRYRIVGDRVVI
GSVRHGARRPL

Nucleotide

• Length: 276 bp

>T115298 NZ_CP034122:3391845-3392120 [Caulobacter vibrioides]
GTGGCGCAAGTAGTCTGGACCCAACGAGCGATGGCCGATGTTTACGCCATCGTCGGCCATATCTCCGAGCAGTCGCGTCC
TCTCGCGGCCCAGCGCCTGGCCAAGAGGTTGTTCGACACCGGCGCTAGCCTGGCGACCTATCCCGAACGCGGGCGCGTGA
GCACTCAAGGACGGCGAGAGATCGTCGCGATTTCGCCCTACGTTCTGCGCTACCGCATTGTCGGCGACCGTGTCGTCATT
GGCAGCGTACGCCATGGGGCGCGTCGACCTCTCTAG

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6606.17 Da
• Isoelectric Point: 3.9689

>AT115298 WP_012640671.1 NZ_CP034122:3391678-3391857 [Caulobacter vibrioides]
MAEPDPDIFDEDDEAILAADAEADADFEAGRTVPHERVGEWLKTLGTPHQTPPPYSWRK

Nucleotide

• Length: 180 bp

>AT115298 NZ_CP034122:3391678-3391857 [Caulobacter vibrioides]
ATGGCCGAGCCTGACCCCGACATCTTCGACGAGGACGATGAAGCGATCCTGGCGGCTGACGCCGAGGCTGACGCCGACTT
CGAAGCCGGTAGAACTGTTCCGCACGAGCGTGTGGGCGAGTGGCTCAAGACGTTGGGCACGCCGCACCAGACACCGCCAC
CATATTCGTGGCGCAAGTAG

Structures

Antitoxin

• AlphaFold DB: P0CW75