Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3005987..3007650 Replicon chromosome
Accession NZ_CP034122
Organism Caulobacter vibrioides strain CB2A

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag EIB18_RS14690 Protein ID WP_096033974.1
Coordinates 3005987..3007294 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag EIB18_RS14695 Protein ID WP_010920612.1
Coordinates 3007291..3007650 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIB18_RS14660 3001173..3002543 - 1371 WP_096033971.1 hypothetical protein -
EIB18_RS14665 3002704..3004095 - 1392 WP_096034807.1 sensor histidine kinase -
EIB18_RS14670 3004137..3004814 - 678 WP_010920607.1 response regulator transcription factor -
EIB18_RS14675 3004830..3005147 - 318 WP_010920608.1 PepSY domain-containing protein -
EIB18_RS14680 3005276..3005785 - 510 WP_096033972.1 hypothetical protein -
EIB18_RS14690 3005987..3007294 - 1308 WP_096033974.1 type II toxin-antitoxin system HipA family toxin Toxin
EIB18_RS14695 3007291..3007650 - 360 WP_010920612.1 helix-turn-helix domain-containing protein Antitoxin
EIB18_RS14700 3007813..3008760 - 948 WP_096033975.1 J domain-containing protein -
EIB18_RS14705 3008849..3012559 - 3711 WP_205685752.1 glycoside hydrolase TIM-barrel-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(170-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 47789.19 Da        Isoelectric Point: 7.0752

>T115297 WP_096033974.1 NZ_CP034122:c3007294-3005987 [Caulobacter vibrioides]
MTTVAEVRLWGSRIGAVSLEDGAQTAVFAYEPGFIASGIQPAPLMMPLKAGVFSFPDLPPRSFHGLPGMLADALPDKYGH
VLIDAWLATQGRSPESFNAVERLCYTGRRGMGALEFSPMAGPRRRVSSKIDIDALVTLASEVLTHRHDLRASFADADKAD
ALRDILSVGTSAGGARAKAVIAWNPATNEVRSGQVEAGAGFGYWLLKFDGVSGNRDKELADPKGYGAVEHAYGQMAAAAG
IDVAESRLLEEGGRRHFMSKRFDRLDGGGKLHMQSLAAIAHLDFNDPVANSYEQALFTMRRMGLPMAQLEEQFRRMVFNV
LARNQDDHVKNIAFLMDRAGRWSLSPAFDITWSYNPDGEWTSRHQMSINGKRDGFDFADLEACAKTASISRGHVGRIFEE
VRAAVMRWPTFADAAGVDERWRDQIGATLRLELRR

Download         Length: 1308 bp

>T115297 NZ_CP034122:c3007294-3005987 [Caulobacter vibrioides]
ATGACCACCGTCGCCGAGGTTCGCCTGTGGGGCAGCCGGATCGGCGCGGTGTCGCTGGAAGACGGCGCCCAGACGGCGGT
CTTCGCCTATGAGCCGGGCTTTATCGCCAGCGGAATCCAGCCCGCCCCGCTGATGATGCCGCTGAAGGCCGGCGTGTTCA
GCTTTCCCGATCTGCCGCCGCGCAGCTTCCATGGCCTGCCCGGCATGCTGGCCGACGCCCTGCCGGACAAGTACGGCCAT
GTGCTGATCGACGCCTGGCTGGCCACGCAAGGTCGCAGCCCCGAGAGCTTCAACGCCGTCGAGCGCCTTTGCTACACCGG
CCGCCGGGGCATGGGGGCGCTGGAGTTCTCGCCGATGGCGGGGCCGCGTCGGCGGGTCTCCAGCAAGATCGACATCGACG
CCCTGGTGACCCTGGCTTCGGAGGTGCTGACCCATCGCCACGACCTGCGCGCCTCGTTCGCCGATGCGGACAAGGCCGAC
GCCCTGCGCGACATCTTGAGCGTCGGCACCTCGGCGGGCGGGGCGCGGGCCAAGGCGGTGATCGCCTGGAACCCGGCAAC
CAACGAAGTGCGCTCCGGTCAGGTCGAGGCGGGCGCGGGTTTCGGCTACTGGCTGCTGAAGTTCGACGGCGTCTCCGGCA
ACCGGGACAAGGAACTGGCCGACCCCAAGGGCTATGGCGCGGTCGAGCACGCCTATGGACAGATGGCGGCGGCGGCGGGA
ATCGACGTCGCCGAGAGTCGCTTGCTGGAGGAGGGCGGTCGTCGCCACTTCATGAGCAAGCGCTTCGACCGGCTGGACGG
CGGCGGCAAGCTGCACATGCAGTCGCTGGCCGCCATCGCCCATCTGGATTTCAACGATCCCGTCGCCAATTCCTATGAAC
AGGCCCTGTTCACGATGCGGCGGATGGGCCTGCCGATGGCGCAGTTGGAAGAGCAGTTCCGGCGCATGGTCTTCAACGTG
TTGGCGCGAAACCAGGACGACCACGTCAAGAACATCGCCTTCCTGATGGACCGCGCAGGACGCTGGAGCCTGTCACCGGC
CTTCGACATCACCTGGAGCTACAATCCGGACGGCGAATGGACCTCGCGCCACCAGATGTCGATCAACGGCAAGCGGGACG
GGTTCGACTTCGCCGATCTGGAGGCCTGCGCGAAAACCGCCTCGATCAGTCGCGGTCATGTCGGCCGGATCTTTGAAGAG
GTGCGGGCGGCCGTGATGCGCTGGCCGACCTTCGCCGACGCGGCCGGCGTGGACGAGCGCTGGCGGGATCAGATCGGCGC
GACGCTGCGGCTGGAGCTCAGGCGGTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13019.91 Da        Isoelectric Point: 10.1741

>AT115297 WP_010920612.1 NZ_CP034122:c3007650-3007291 [Caulobacter vibrioides]
MKFESLLSDEAVLAEMGQRLVAARLERRLTQAQLAQAAGVSKRTVERLEDGASAQLTNLVRCLRALDRLEGLERLLPETP
ANPLDLLKQAKTGRSRVRNARASGVAETGGAPWVWGDEK

Download         Length: 360 bp

>AT115297 NZ_CP034122:c3007650-3007291 [Caulobacter vibrioides]
ATGAAATTTGAATCTCTCCTGTCCGATGAGGCGGTGTTGGCCGAGATGGGTCAGCGTCTGGTGGCGGCGCGGCTGGAGCG
GCGGCTGACCCAGGCTCAGCTGGCGCAGGCCGCCGGCGTGTCCAAGCGCACCGTCGAGCGTCTGGAAGACGGCGCCTCGG
CCCAGCTGACCAATCTGGTGCGCTGCCTGCGGGCCCTGGACCGGCTGGAGGGGCTGGAGCGCCTGCTGCCCGAGACGCCC
GCCAATCCGCTGGACCTGCTGAAACAGGCCAAGACCGGCCGCTCAAGAGTGCGCAACGCCCGCGCGTCCGGCGTCGCCGA
GACCGGCGGCGCGCCTTGGGTGTGGGGCGATGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References