Detailed information of TA system TA115294

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 496375..497878
• Replicon: chromosome
• Accession: NZ_CP034122
• Organism: Caulobacter vibrioides strain CB2A

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: A0A0H3C5Z1
• Locus tag: EIB18_RS02440
• Protein ID: WP_012639983.1
• Coordinates: 496607..497878 (+)
• Length: 424 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: EIB18_RS02435
• Protein ID: WP_024265556.1
• Coordinates: 496375..496620 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIB18_RS02410	492349..492732	-	384	WP_012639977.1	hypothetical protein	-
EIB18_RS02415	493113..493307	-	195	WP_012639978.1	excisionase	-
EIB18_RS02420	493429..494166	-	738	WP_012639979.1	hypothetical protein	-
EIB18_RS02425	494355..494678	+	324	WP_012639980.1	helix-turn-helix domain-containing protein	-
EIB18_RS02430	494747..496045	-	1299	WP_024265555.1	site-specific integrase	-
EIB18_RS02435	496375..496620	+	246	WP_024265556.1	helix-turn-helix transcriptional regulator	Antitoxin
EIB18_RS02440	496607..497878	+	1272	WP_012639983.1	type II toxin-antitoxin system HipA family toxin	Toxin
EIB18_RS02450	498402..499247	-	846	WP_164468056.1	MBL fold metallo-hydrolase	-
EIB18_RS02455	499337..500044	-	708	WP_096032393.1	hypothetical protein	-
EIB18_RS02460	500143..501171	-	1029	WP_096032394.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-105)

Antitoxin

• Transcription regulator, HipB-like (12-68)

Sequences

Toxin

Protein

• Length: 424 a.a.
• Molecular weight: 45484.22 Da
• Isoelectric Point: 7.3296

>T115294 WP_012639983.1 NZ_CP034122:496607-497878 [Caulobacter vibrioides]
VAMTRVLTVWWGDGVVGSLALDETGDIRFAYDAAWLADEACPAVSVSLPKQPGAFSRRKTRSFFAGLLPDDLQRDNVARA
LGVSRQNDFGLLERLGGDVAGALTLWPEGEAPPKRQGGRTAEPLNDKRLLAILDELPRRPFLAGEDGVRLSLAGAQEKLP
VVLVDGAVALPALGQPSTHILKPANARWPAMTENEALAMRLAAAVGLPTAGVEPRRIGERTFLLVTRYDRVVSSDGAVRR
LHQEDFCQALGVSPEHKYAAEGGPIFPDCFNLVRNVCQPSAPAVLALLDAAIFNVIVGNADAHGKNYSLLHQAGAIVMAP
LYDLMCTAAYPEVHAKLAMKIAGRAQLEAFKADTWRDFGRDIGMGPAFVERRANAQARRVLDQVGPVADAIAACGFDREA
LRGLRDLIAERARAVLKLGQGER

Nucleotide

• Length: 1272 bp

>T115294 NZ_CP034122:496607-497878 [Caulobacter vibrioides]
GTGGCGATGACTAGAGTGCTGACGGTCTGGTGGGGTGACGGCGTTGTCGGTTCGCTCGCGCTCGACGAGACCGGCGACAT
CCGTTTTGCCTATGACGCTGCCTGGCTGGCCGATGAGGCCTGTCCGGCCGTGTCGGTGTCCTTGCCTAAACAACCTGGCG
CCTTCAGCCGCCGCAAGACGCGCTCGTTCTTCGCGGGCCTGCTGCCTGACGACTTGCAGCGGGACAATGTCGCTCGGGCC
CTCGGTGTTTCCAGGCAGAACGACTTTGGCCTGCTGGAGCGCCTGGGCGGCGACGTCGCCGGCGCGCTCACACTCTGGCC
GGAGGGGGAGGCGCCTCCAAAGCGCCAAGGGGGGCGGACCGCTGAGCCGCTAAACGACAAGCGCCTGCTCGCCATTCTCG
ATGAGCTGCCCCGCCGCCCCTTCCTGGCCGGCGAAGACGGCGTTCGCTTGTCCCTCGCGGGCGCCCAGGAGAAGCTGCCA
GTCGTTCTGGTCGACGGAGCTGTTGCTCTGCCCGCGCTCGGCCAGCCCAGCACCCATATCCTCAAGCCAGCGAACGCACG
GTGGCCGGCCATGACGGAGAACGAGGCCCTTGCCATGCGGCTGGCGGCCGCTGTTGGGCTGCCGACGGCGGGTGTAGAGC
CGCGCAGGATCGGTGAGCGCACCTTTCTGCTGGTCACCCGCTATGACCGGGTCGTCAGCTCAGACGGTGCGGTGCGTCGC
CTGCACCAAGAAGACTTCTGCCAAGCGCTTGGCGTCTCGCCGGAACACAAATACGCGGCCGAGGGCGGGCCGATCTTTCC
GGACTGCTTCAACCTCGTCCGCAACGTCTGTCAGCCGTCCGCGCCGGCGGTGCTGGCGCTGCTCGATGCGGCGATTTTCA
ACGTCATCGTCGGCAACGCCGACGCTCACGGCAAGAACTACAGCCTGCTCCACCAAGCCGGCGCAATCGTCATGGCGCCG
CTCTATGACCTGATGTGCACGGCCGCCTATCCCGAGGTCCACGCCAAGCTGGCCATGAAGATCGCTGGGCGCGCCCAACT
GGAGGCGTTCAAGGCCGACACCTGGCGTGACTTCGGGCGCGATATCGGCATGGGTCCGGCGTTCGTTGAGCGTCGCGCGA
ACGCCCAAGCGCGACGGGTGCTCGACCAGGTGGGGCCCGTCGCCGACGCCATCGCCGCTTGCGGCTTTGACCGCGAGGCG
CTGCGCGGCTTGCGCGACCTGATCGCGGAGCGGGCGAGAGCCGTCCTGAAACTGGGTCAGGGCGAGCGCTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8434.82 Da
• Isoelectric Point: 10.6826

>AT115294 WP_024265556.1 NZ_CP034122:496375-496620 [Caulobacter vibrioides]
MTLLRQGLDAAALGAQVRRARRAMGLRQDELAAAAGVGLRFLVELERGKPTVQLGKVLDVLAAAGLDLQLVSRAPVSGGD
D

Nucleotide

• Length: 246 bp

>AT115294 NZ_CP034122:496375-496620 [Caulobacter vibrioides]
ATGACCCTCCTCCGGCAAGGCCTGGACGCCGCAGCGCTAGGGGCGCAGGTGCGTCGGGCCCGTAGGGCTATGGGGCTGCG
ACAGGACGAGCTGGCCGCTGCTGCGGGCGTTGGCCTCCGGTTCCTCGTCGAGCTCGAAAGAGGCAAGCCGACGGTTCAGT
TGGGCAAGGTCTTGGATGTCCTGGCCGCCGCTGGCCTGGATCTGCAACTGGTCAGCCGTGCTCCGGTGAGCGGTGGCGAT
GACTAG

Structures

Toxin

• AlphaFold DB: A0A0H3C5Z1