Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1525927..1526456 Replicon chromosome
Accession NZ_CP034115
Organism Staphylococcus epidermidis strain CDC121

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag EH163_RS07680 Protein ID WP_001829891.1
Coordinates 1526094..1526456 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag EH163_RS07675 Protein ID WP_001829931.1
Coordinates 1525927..1526097 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH163_RS07650 1521752..1522231 + 480 WP_001829909.1 PH domain-containing protein -
EH163_RS07655 1522224..1523729 + 1506 WP_001829976.1 PH domain-containing protein -
EH163_RS07660 1523716..1524225 + 510 WP_001829888.1 PH domain-containing protein -
EH163_RS07665 1524273..1524626 + 354 WP_001829915.1 holo-ACP synthase -
EH163_RS07670 1524692..1525840 + 1149 WP_001829972.1 alanine racemase -
EH163_RS07675 1525927..1526097 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EH163_RS07680 1526094..1526456 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EH163_RS07685 1526802..1527803 + 1002 WP_124743126.1 PP2C family protein-serine/threonine phosphatase -
EH163_RS07690 1527903..1528229 + 327 WP_001829952.1 anti-sigma factor antagonist -
EH163_RS07695 1528231..1528710 + 480 WP_001829903.1 anti-sigma B factor RsbW -
EH163_RS07700 1528685..1529455 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T115291 WP_001829891.1 NZ_CP034115:1526094-1526456 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T115291 NZ_CP034115:1526094-1526456 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTGAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT115291 WP_001829931.1 NZ_CP034115:1525927-1526097 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT115291 NZ_CP034115:1525927-1526097 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References