Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1514752..1515261 Replicon chromosome
Accession NZ_CP034115
Organism Staphylococcus epidermidis strain CDC121

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag EH163_RS07620 Protein ID WP_001829980.1
Coordinates 1515052..1515261 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag EH163_RS07615 Protein ID WP_001829893.1
Coordinates 1514752..1515045 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH163_RS07590 1509760..1510548 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
EH163_RS07595 1510554..1511192 + 639 WP_002505076.1 thiamine phosphate synthase -
EH163_RS07600 1511281..1512153 + 873 WP_002458703.1 membrane protein insertase YidC -
EH163_RS07605 1512259..1512912 - 654 WP_001829983.1 HD domain-containing protein -
EH163_RS07610 1513094..1514578 - 1485 WP_002457116.1 cardiolipin synthase -
EH163_RS07615 1514752..1515045 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
EH163_RS07620 1515052..1515261 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
EH163_RS07625 1515404..1515541 + 138 WP_001829949.1 hypothetical protein -
EH163_RS07630 1515641..1516844 - 1204 Protein_1409 rod shape-determining protein RodA -
EH163_RS07635 1517235..1518308 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
EH163_RS07640 1518320..1519675 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T115290 WP_001829980.1 NZ_CP034115:1515052-1515261 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T115290 NZ_CP034115:1515052-1515261 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT115290 WP_001829893.1 NZ_CP034115:1514752-1515045 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT115290 NZ_CP034115:1514752-1515045 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References