Detailed information of TA system TA115284

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1486765..1487352
• Replicon: chromosome
• Accession: NZ_CP034110
• Organism: Avibacterium paragallinarum strain FARPER-174

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EIA51_RS07050
• Protein ID: WP_103846679.1
• Coordinates: 1486765..1487028 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8W4K1
• Locus tag: EIA51_RS07055
• Protein ID: WP_035686016.1
• Coordinates: 1487062..1487352 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIA51_RS07025	1481798..1482412	-	615	WP_046097415.1	Holliday junction branch migration protein RuvA	-
EIA51_RS07030	1482500..1483060	-	561	WP_035685784.1	crossover junction endodeoxyribonuclease RuvC	-
EIA51_RS07035	1483136..1483876	-	741	WP_035685786.1	YebC/PmpR family DNA-binding transcriptional regulator	-
EIA51_RS07040	1484329..1484772	-	444	WP_035685789.1	dihydroneopterin triphosphate diphosphatase	-
EIA51_RS07045	1484898..1486676	-	1779	WP_035685792.1	aspartate--tRNA ligase	-
EIA51_RS07050	1486765..1487028	-	264	WP_103846679.1	type II toxin-antitoxin system YafQ family toxin	Toxin
EIA51_RS07055	1487062..1487352	-	291	WP_035686016.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EIA51_RS07060	1487544..1488269	+	726	WP_035685795.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
EIA51_RS07065	1488390..1489343	-	954	WP_124994836.1	porin	-
EIA51_RS07070	1489288..1489470	-	183	WP_124994837.1	hypothetical protein	-
EIA51_RS07075	1489693..1490760	-	1068	WP_046097416.1	porin	-
EIA51_RS07080	1491033..1492145	-	1113	WP_035685801.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10200.10 Da
• Isoelectric Point: 9.1425

>T115284 WP_103846679.1 NZ_CP034110:c1487028-1486765 [Avibacterium paragallinarum]
MAKEFKRDLVQLAKKAPHLFVHPRYLEVMHCLTNGLTLPAEYKNHPLKNNLKGYMDCHILNDLVLIYKIEQQCLKLVRLN
THSEVFA

Nucleotide

• Length: 264 bp

>T115284 NZ_CP034110:c1487028-1486765 [Avibacterium paragallinarum]
ATGGCGAAAGAATTTAAGCGCGATTTGGTACAACTAGCCAAAAAAGCACCGCACTTATTTGTTCATCCCCGCTATTTGGA
AGTGATGCACTGCTTAACAAATGGACTGACTTTACCCGCCGAATATAAAAATCATCCGCTTAAAAACAATTTGAAAGGTT
ATATGGATTGCCACATTCTCAATGATCTCGTGCTAATTTATAAAATTGAACAGCAATGCCTAAAATTAGTTCGGCTAAAT
ACACATTCAGAAGTTTTTGCATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10716.23 Da
• Isoelectric Point: 4.7185

>AT115284 WP_035686016.1 NZ_CP034110:c1487352-1487062 [Avibacterium paragallinarum]
MTNNNAVVNFRLPQHLKTEAFEVIAQYGLTPSQVFNMFLTEIATTKAIPLSLNYLQPNAKTLAAMNEIESGTAERFSLDD
KTDLATLLQQIAEEKK

Nucleotide

• Length: 291 bp

>AT115284 NZ_CP034110:c1487352-1487062 [Avibacterium paragallinarum]
ATGACGAACAATAATGCCGTGGTGAATTTTCGTTTACCACAACATTTAAAAACAGAAGCATTTGAAGTGATTGCTCAATA
TGGCCTTACTCCATCACAAGTGTTTAATATGTTTTTAACTGAAATTGCTACCACCAAAGCAATTCCTTTGAGTTTGAATT
ATTTACAACCTAATGCAAAAACTTTAGCGGCAATGAATGAAATTGAAAGTGGAACGGCTGAGCGTTTCTCTCTTGATGAT
AAAACCGATCTTGCCACCTTATTGCAACAAATAGCAGAAGAGAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A3G8W4K1