Detailed information of TA system TA115282

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1159945..1161578
• Replicon: chromosome
• Accession: NZ_CP034110
• Organism: Avibacterium paragallinarum strain FARPER-174

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A3G8W245
• Locus tag: EIA51_RS05660
• Protein ID: WP_035684858.1
• Coordinates: 1159945..1161252 (+)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: EIA51_RS05665
• Protein ID: WP_081637498.1
• Coordinates: 1161252..1161578 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIA51_RS05635	1155308..1156342	+	1035	WP_035684872.1	thiamine-phosphate kinase	-
EIA51_RS05640	1156348..1156848	+	501	WP_017806513.1	phosphatidylglycerophosphatase A	-
EIA51_RS05645	1156860..1157495	+	636	WP_035684869.1	LysE family transporter	-
EIA51_RS05650	1157510..1158322	+	813	WP_035684866.1	4-hydroxy-tetrahydrodipicolinate reductase	-
EIA51_RS05655	1159597..1159845	+	249	WP_035684861.1	2Fe-2S ferredoxin-like protein	-
EIA51_RS05660	1159945..1161252	+	1308	WP_035684858.1	HipA domain-containing protein	Toxin
EIA51_RS05665	1161252..1161578	+	327	WP_081637498.1	helix-turn-helix domain-containing protein	Antitoxin
EIA51_RS05670	1161619..1162749	-	1131	WP_035684855.1	ribonucleotide-diphosphate reductase subunit beta	-
EIA51_RS05675	1162912..1163334	-	423	WP_035684853.1	DUF1043 family protein	-
EIA51_RS05680	1163469..1165238	-	1770	WP_035684851.1	30S ribosomal protein S12 methylthiotransferase accessory factor YcaO	-
EIA51_RS05685	1165345..1166076	-	732	WP_035684848.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (158-351)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 50363.28 Da
• Isoelectric Point: 5.6627

>T115282 WP_035684858.1 NZ_CP034110:1159945-1161252 [Avibacterium paragallinarum]
MEKLTLQTYIDQEWRDMAELHFEKETYQLSNLVYFPDYITQYFGQEGSRAVSINYPVHIFIENRKTLWSCIGDIAPAGAS
RRYWIESLDIKHLPESEQNYRLLKYGAISPVGNLRIKEATPQKTEVRYFDIEKVKDRQSDFLEYANQSGAMVGGATGAGG
EAPKLLLKRHNGKVWIDNLQDGKDQDISYLVKYPRGRYSPIDCDILRAEFHYYQEVAELGFDTIDIHHMCLEEGERYPSL
WLPRFDITKKEGKYNRLALESVYSMLQKQGGTLEHEVTIRQLIKIISASNLEFDQQHFVLEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQKIWLAPIYDFAPMRADPEGIIRSTTWNRKGSLPQEFAGEYRFDLIAESLSDLIEPSLLLTELQQLAIRLVD
LKSRLAQRGVPQAILDHPSIGFDYLPEKLKAWGLV

Nucleotide

• Length: 1308 bp

>T115282 NZ_CP034110:1159945-1161252 [Avibacterium paragallinarum]
ATGGAAAAATTAACACTTCAGACTTATATTGATCAAGAATGGCGGGATATGGCTGAGCTTCATTTTGAAAAGGAAACCTA
TCAACTATCCAATCTTGTTTATTTTCCCGATTATATTACGCAGTATTTCGGGCAAGAAGGCTCTCGTGCAGTTTCAATTA
ATTACCCTGTCCATATTTTTATTGAAAATCGAAAAACATTGTGGTCTTGCATTGGTGATATTGCCCCAGCTGGAGCAAGT
CGTCGTTATTGGATTGAAAGTTTAGATATTAAGCATTTACCTGAATCTGAACAAAATTACCGATTATTGAAATATGGTGC
GATTTCACCAGTGGGAAATTTACGTATAAAGGAAGCGACGCCTCAAAAAACAGAAGTACGTTATTTTGATATTGAAAAAG
TCAAAGATCGCCAAAGTGATTTTCTTGAATATGCTAATCAAAGCGGTGCTATGGTGGGCGGTGCAACAGGTGCTGGCGGT
GAAGCACCTAAACTATTATTAAAACGTCATAATGGTAAAGTTTGGATTGATAATCTGCAAGATGGAAAAGATCAAGATAT
TAGTTATTTAGTAAAATATCCTCGTGGACGTTATTCACCCATTGATTGTGATATTTTGCGTGCGGAATTTCATTATTATC
AAGAAGTAGCTGAATTAGGTTTTGATACTATCGATATTCACCATATGTGCCTTGAAGAAGGCGAGCGTTATCCATCGCTT
TGGTTGCCACGTTTCGATATTACAAAGAAAGAGGGAAAATACAACCGTTTGGCTTTAGAGTCTGTTTATTCAATGTTACA
AAAACAAGGTGGAACATTAGAACACGAAGTGACAATTCGTCAATTAATAAAAATAATTTCTGCTTCAAATTTGGAATTTG
ATCAGCAACATTTTGTCCTTGAGTGGGTTAAACGAGATTTACTGAATATTGCCTTTGGGAATAGTGATAATCACGGTAGA
AATATGGCTTTTTTGCGAGATGAACAAAAAATCTGGCTTGCACCAATTTATGATTTTGCACCAATGCGTGCTGATCCTGA
GGGGATTATCCGTTCAACAACGTGGAATCGAAAAGGGAGTTTGCCACAAGAATTTGCAGGTGAATATCGATTTGATTTAA
TTGCAGAGTCATTGTCTGACCTTATTGAACCGAGTTTGTTGCTTACAGAACTACAACAACTCGCAATAAGGTTAGTGGAT
TTAAAATCACGCTTAGCACAACGCGGTGTGCCACAAGCTATTTTAGATCATCCCTCCATTGGATTTGATTATTTGCCAGA
AAAACTAAAAGCATGGGGGCTTGTGTAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12252.39 Da
• Isoelectric Point: 10.9810

>AT115282 WP_081637498.1 NZ_CP034110:1161252-1161578 [Avibacterium paragallinarum]
MITRKNASKVGATISTTERNNVRNRIIKALLLGKMTQGQALRKLRIEMLGVNQQQYMKVVKVSRQTLSNIENDKGNYSVE
TINQVFKPFGFELGLVPISKELLTEIMQ

Nucleotide

• Length: 327 bp

>AT115282 NZ_CP034110:1161252-1161578 [Avibacterium paragallinarum]
ATGATAACAAGAAAAAATGCGTCTAAAGTTGGTGCAACGATTTCTACAACTGAACGTAATAATGTTAGAAATAGAATTAT
CAAAGCGTTGTTATTAGGTAAAATGACGCAAGGACAGGCACTGCGTAAATTACGCATAGAAATGCTTGGCGTTAATCAGC
AACAATATATGAAGGTGGTTAAGGTTTCACGTCAAACCCTTTCTAATATAGAAAATGACAAAGGAAATTACAGCGTTGAA
ACCATAAATCAAGTATTCAAACCCTTTGGATTTGAGTTGGGATTAGTGCCTATTTCTAAAGAGTTACTCACTGAAATTAT
GCAATAA

Structures

Toxin

• AlphaFold DB: A0A3G8W245