Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 919609..920195 Replicon chromosome
Accession NZ_CP034110
Organism Avibacterium paragallinarum strain FARPER-174

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G8W1K6
Locus tag EIA51_RS04580 Protein ID WP_035687070.1
Coordinates 919947..920195 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3G8VZN0
Locus tag EIA51_RS04575 Protein ID WP_035687072.1
Coordinates 919609..919950 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIA51_RS04555 914861..915787 - 927 WP_035687084.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
EIA51_RS04560 915796..917769 - 1974 WP_124994814.1 DNA mismatch repair endonuclease MutL -
EIA51_RS04565 917778..919025 - 1248 WP_035687078.1 N-acetylmuramoyl-L-alanine amidase -
EIA51_RS04570 919038..919514 - 477 WP_035687075.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
EIA51_RS04575 919609..919950 - 342 WP_035687072.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EIA51_RS04580 919947..920195 - 249 WP_035687070.1 type II toxin-antitoxin system HicA family toxin Toxin
EIA51_RS04585 920255..921706 - 1452 WP_046097372.1 glycoside hydrolase family 32 protein -
EIA51_RS04590 921725..922654 - 930 WP_035688523.1 aminoimidazole riboside kinase -
EIA51_RS04595 922964..924163 - 1200 WP_035688521.1 tyrosine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9219.85 Da        Isoelectric Point: 10.2543

>T115281 WP_035687070.1 NZ_CP034110:c920195-919947 [Avibacterium paragallinarum]
MGKSEKLLEKLANAKNTFIWTDLLTLLARLGYEKREMAGSRVRFYNAELDHLILLHKPHPENYIKGGALKSVKEGLKGAG
LL

Download         Length: 249 bp

>T115281 NZ_CP034110:c920195-919947 [Avibacterium paragallinarum]
ATGGGAAAATCTGAAAAATTATTAGAAAAATTAGCTAACGCTAAAAACACCTTTATTTGGACAGATTTACTCACCTTATT
AGCTCGGTTAGGCTATGAAAAACGTGAAATGGCTGGCTCTCGTGTTAGATTTTACAACGCAGAGCTTGATCACTTAATCT
TGTTACATAAACCGCACCCTGAAAATTACATTAAAGGTGGTGCGTTAAAATCGGTTAAAGAGGGATTAAAAGGAGCGGGA
TTGTTATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12710.50 Da        Isoelectric Point: 4.5942

>AT115281 WP_035687072.1 NZ_CP034110:c919950-919609 [Avibacterium paragallinarum]
MTLLKYKGYVGTIEADLENNVLFGKLAYIRDVITYEAETLPQLEKEFQTSVDLYLQDCQELGRTPDKPFKGVFNVRISEE
LHRNAVLAAGDLSLNAFVAEAIKEKVERAGITN

Download         Length: 342 bp

>AT115281 NZ_CP034110:c919950-919609 [Avibacterium paragallinarum]
ATGACCTTACTCAAATATAAAGGCTATGTCGGCACAATTGAAGCCGATTTAGAAAATAATGTGCTATTTGGAAAATTGGC
TTATATACGCGATGTTATCACCTACGAAGCGGAAACTTTGCCACAATTAGAGAAAGAATTTCAAACTTCTGTGGATCTGT
ATTTGCAAGATTGCCAAGAACTTGGGCGAACGCCTGACAAACCTTTCAAAGGCGTATTTAATGTGAGAATTAGCGAAGAA
CTTCACCGTAATGCCGTGTTAGCTGCAGGTGATCTTAGCTTGAATGCCTTTGTTGCTGAAGCAATTAAAGAAAAAGTAGA
ACGTGCTGGCATTACAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G8W1K6

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8VZN0

References