Detailed information of TA system TA115280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 498990..499530
• Replicon: chromosome
• Accession: NZ_CP034110
• Organism: Avibacterium paragallinarum strain FARPER-174

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A3G8VZS8
• Locus tag: EIA51_RS02655
• Protein ID: WP_035688134.1
• Coordinates: 499240..499530 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8W1I3
• Locus tag: EIA51_RS02650
• Protein ID: WP_035688131.1
• Coordinates: 498990..499250 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIA51_RS11790	494311..494469	+	159	WP_168977192.1	hypothetical protein	-
EIA51_RS02630	495116..496327	+	1212	WP_035688123.1	tyrosine-type recombinase/integrase	-
EIA51_RS11685	496558..496707	-	150	WP_156127747.1	hypothetical protein	-
EIA51_RS02635	496987..497193	+	207	WP_035688126.1	AlpA family phage regulatory protein	-
EIA51_RS02640	497197..497874	+	678	WP_035688128.1	hypothetical protein	-
EIA51_RS02645	497886..498851	+	966	WP_035688129.1	P2 family phage major capsid protein	-
EIA51_RS02650	498990..499250	+	261	WP_035688131.1	stability protein StbD	Antitoxin
EIA51_RS02655	499240..499530	+	291	WP_035688134.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EIA51_RS02660	499572..500672	+	1101	WP_051128101.1	hypothetical protein	-
EIA51_RS02665	500836..501051	+	216	WP_035688136.1	helix-turn-helix domain-containing protein	-
EIA51_RS02670	501062..501367	+	306	WP_035688139.1	hypothetical protein	-
EIA51_RS02675	501471..502043	+	573	WP_051128102.1	ash family protein	-
EIA51_RS02680	502036..502266	+	231	WP_035688141.1	hypothetical protein	-
EIA51_RS02685	502259..502528	+	270	WP_035688144.1	hypothetical protein	-
EIA51_RS02690	502533..502757	+	225	WP_035688166.1	hypothetical protein	-
EIA51_RS02695	502757..503098	+	342	WP_035688146.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	htpB	492843..517807	24964

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11399.31 Da
• Isoelectric Point: 10.6318

>T115280 WP_035688134.1 NZ_CP034110:499240-499530 [Avibacterium paragallinarum]
MTYKLSFDKRALKEWHKLGDTLRQQFKAKLIERLENPHVLSDKLHGYQTLYKIKLRSAGYRLVYDVNDNEIRVIVLSVGK
REHLQAYKKALSRKAQ

Nucleotide

• Length: 291 bp

>T115280 NZ_CP034110:499240-499530 [Avibacterium paragallinarum]
ATGACCTATAAACTTTCTTTTGATAAACGGGCATTAAAAGAATGGCATAAATTGGGCGATACCCTACGCCAGCAATTTAA
AGCAAAATTAATCGAGCGGCTGGAAAATCCCCACGTTTTAAGCGATAAATTGCACGGTTATCAAACGCTTTATAAAATTA
AATTGCGATCAGCGGGCTATCGGCTTGTTTATGATGTCAATGACAATGAAATTAGAGTTATTGTGCTTTCAGTAGGCAAA
AGAGAACACCTACAAGCCTATAAAAAAGCCCTATCAAGAAAAGCCCAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9550.98 Da
• Isoelectric Point: 4.1813

>AT115280 WP_035688131.1 NZ_CP034110:498990-499250 [Avibacterium paragallinarum]
MAIQQILTRHTASISDLKKNPMGIVSEGTEQEGAIAILNRNEPVFYCVNPCLFAVIQEILEDKELGELATQRLATLDPVE
VRLDDL

Nucleotide

• Length: 261 bp

>AT115280 NZ_CP034110:498990-499250 [Avibacterium paragallinarum]
ATGGCAATTCAGCAAATTTTAACCCGCCACACGGCAAGCATTAGCGACTTGAAAAAAAATCCTATGGGGATTGTATCAGA
GGGAACAGAGCAAGAAGGGGCGATCGCTATTCTAAACCGTAATGAACCCGTGTTTTATTGCGTAAATCCCTGTCTTTTTG
CGGTTATTCAAGAAATCCTTGAAGACAAAGAACTAGGCGAACTCGCCACACAACGCCTTGCAACCCTTGACCCCGTCGAG
GTGCGTTTAGATGACCTATAA

Structures

Toxin

• AlphaFold DB: A0A3G8VZS8

Antitoxin

• AlphaFold DB: A0A3G8W1I3