Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4134965..4136536 Replicon chromosome
Accession NZ_CP034105
Organism Proteus sp. GOKU

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EHE21_RS18825 Protein ID WP_194951535.1
Coordinates 4134965..4136278 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EHE21_RS18830 Protein ID WP_072070485.1
Coordinates 4136279..4136536 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHE21_RS18810 4130305..4132386 + 2082 Protein_3649 TonB-dependent receptor -
EHE21_RS18815 4132467..4133246 + 780 WP_194951534.1 ABC transporter ATP-binding protein -
EHE21_RS18820 4133343..4133804 - 462 WP_088494149.1 DUF1097 domain-containing protein -
EHE21_RS18825 4134965..4136278 - 1314 WP_194951535.1 type II toxin-antitoxin system HipA family toxin Toxin
EHE21_RS18830 4136279..4136536 - 258 WP_072070485.1 helix-turn-helix domain-containing protein Antitoxin
EHE21_RS18835 4136685..4138049 - 1365 WP_023583363.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
EHE21_RS18840 4138180..4139820 - 1641 WP_194951536.1 membrane protein insertase YidC -
EHE21_RS18845 4139823..4140083 - 261 WP_072064717.1 membrane protein insertion efficiency factor YidD -
EHE21_RS18850 4140047..4140406 - 360 WP_071788569.1 ribonuclease P protein component -
EHE21_RS18855 4140424..4140567 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49815.73 Da        Isoelectric Point: 5.8026

>T115245 WP_194951535.1 NZ_CP034105:c4136278-4134965 [Proteus sp. GOKU]
MASLDVYMNEYHVGIFTKKSSGAHSFQYAEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAVGADTVGALRLLPSGSTPANIKKIEYNELDNAELEKILLGYQSNTPLGMLEEYTDFRISIAGAQEKTA
LLLKDDHWCVPHNNTPTTHIIKLPIGVIEGHSYTMDLSDSVENEYLCTLIAKEFDLPVPHCFIVKTENIKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIISIMNYLLGSSNADPDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPYFEGRGFNPRDAKLAMGLQASRRKKYAIEQIFPRHFYQTAEAVGFDPSLMTDILRYFYKEM
DDAIKRVKQQLPDDFPSEIRNKILDGMKARSARLANI

Download         Length: 1314 bp

>T115245 NZ_CP034105:c4136278-4134965 [Proteus sp. GOKU]
ATGGCGAGCCTTGATGTGTATATGAATGAATATCATGTGGGCATTTTTACTAAAAAAAGCTCAGGTGCGCATTCATTTCA
ATATGCTGAAGATTGGGTTAATCAACCGGGAAGTCGCCCTATATCTCTTTCTATGCCACTACAACTTCAAGAATATCAAG
GAGATTGTGTCTATAATTTCTTTGATAATCTTTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCAAACTCAAATCAACCATTTGATCTATTAGCTGCCGTGGGTGCGGATACGGTTGGTGCATTACGGTTACTTCCTAGTGG
TAGTACACCAGCTAATATAAAAAAAATAGAATATAACGAACTTGATAACGCTGAACTTGAAAAAATACTATTAGGATATC
AATCCAATACACCACTCGGTATGCTTGAAGAATATACTGATTTCAGAATTTCTATTGCTGGTGCGCAAGAAAAAACAGCA
TTACTTTTAAAAGATGATCATTGGTGCGTACCACATAATAATACGCCGACTACACATATAATTAAGCTACCCATTGGTGT
TATTGAGGGGCATTCCTACACAATGGATTTATCCGATAGTGTAGAAAATGAATATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCTGTTCCTCACTGCTTTATTGTTAAAACAGAAAATATTAAAGCGCTTGCTGTAGAACGCTTTGATAGAAAA
TACTCATCAGATAAATCGTGGATAATACGCTTACCCCAAGAAGATTTTTGCCAAATTCTAAATATACCTTCAGCTCTAAA
ATATGAAAATGAAGGAGGACCTGGCATTATTAGTATAATGAATTATTTGCTTGGTTCATCAAATGCTGATCCAGACCGTT
TTCATTTTATGAAGGCACAAGTACTATTTTGGCTTTTGGCTGCAACAGATGGGCATGCAAAGAATTTCTCTGTTTTTATC
AATCAAGAAGGACGTTTTCACCTCACGCCTCTTTATGACATCATGTCTATCTATCCCTATTTTGAAGGACGAGGGTTTAA
TCCACGAGATGCAAAACTCGCTATGGGATTACAGGCAAGCCGACGCAAAAAATATGCCATAGAGCAAATTTTTCCTCGCC
ATTTTTACCAAACAGCCGAAGCTGTCGGCTTCGATCCTTCATTGATGACAGATATTCTTCGTTATTTTTATAAAGAAATG
GACGATGCCATCAAACGCGTAAAACAACAACTACCTGATGATTTCCCTTCTGAAATTCGCAATAAGATATTGGATGGAAT
GAAAGCTCGCTCGGCAAGATTAGCCAATATTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9848.40 Da        Isoelectric Point: 10.0139

>AT115245 WP_072070485.1 NZ_CP034105:c4136536-4136279 [Proteus sp. GOKU]
MIIINAYQLSVHLKDVRLTKKLSQGKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp

>AT115245 NZ_CP034105:c4136536-4136279 [Proteus sp. GOKU]
ATGATTATAATTAACGCCTATCAACTCAGCGTACATCTAAAAGATGTCCGATTAACAAAAAAACTTTCTCAAGGTAAAGT
CGCCCAAAAAGTGGGAATTCGACAAGACACCGTGTCCAATTTTGAACTTAACCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTACTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCGCACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References