Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 3839699..3840398 Replicon chromosome
Accession NZ_CP034105
Organism Proteus sp. GOKU

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EHE21_RS17530 Protein ID WP_194952709.1
Coordinates 3839699..3840085 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EHE21_RS17535 Protein ID WP_088494342.1
Coordinates 3840078..3840398 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHE21_RS17515 3835737..3836321 - 585 WP_194951383.1 DNA-3-methyladenine glycosylase I -
EHE21_RS17520 3836560..3837465 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
EHE21_RS17525 3837475..3839547 + 2073 WP_194951384.1 glycine--tRNA ligase subunit beta -
EHE21_RS17530 3839699..3840085 + 387 WP_194952709.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHE21_RS17535 3840078..3840398 + 321 WP_088494342.1 helix-turn-helix domain-containing protein Antitoxin
EHE21_RS17540 3840421..3840858 - 438 WP_194951385.1 hypothetical protein -
EHE21_RS17545 3840848..3841735 - 888 WP_194951386.1 endonuclease/exonuclease/phosphatase family protein -
EHE21_RS17550 3841953..3843239 - 1287 WP_194951387.1 DUF3748 domain-containing protein -
EHE21_RS17555 3843376..3843993 + 618 WP_088494339.1 trimeric intracellular cation channel family protein -
EHE21_RS17560 3844299..3844922 + 624 WP_023583250.1 guanylate kinase -
EHE21_RS17565 3844977..3845252 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-96)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14416.77 Da        Isoelectric Point: 9.9198

>T115244 WP_194952709.1 NZ_CP034105:3839699-3840085 [Proteus sp. GOKU]
MVIYKTKMFKNNFKKIPINDADLIDIANEVYAGHFEADLGGGIIKKRICIQGKGKSSGIRTIIFYKQGSNLFFADGWKKS
HLSSKKAKEITDDELESYKDLAKDLFSATKNKIDKMIALGLLTEVKHD

Download         Length: 387 bp

>T115244 NZ_CP034105:3839699-3840085 [Proteus sp. GOKU]
ATGGTTATCTATAAAACAAAGATGTTCAAAAATAATTTCAAGAAAATACCTATCAATGATGCTGATTTAATAGATATTGC
CAACGAAGTATATGCAGGACACTTTGAAGCTGACTTAGGTGGTGGGATTATCAAAAAACGGATCTGTATCCAAGGAAAAG
GAAAGAGTAGTGGAATTAGAACAATTATATTTTATAAACAGGGAAGTAATTTATTCTTTGCTGATGGATGGAAAAAATCT
CACTTAAGTTCTAAAAAAGCGAAAGAAATTACAGATGATGAGCTAGAATCCTATAAAGATCTGGCAAAAGATCTCTTCAG
TGCAACTAAAAATAAAATAGATAAGATGATTGCACTAGGCCTTTTAACGGAGGTTAAACATGACTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12042.00 Da        Isoelectric Point: 10.2405

>AT115244 WP_088494342.1 NZ_CP034105:3840078-3840398 [Proteus sp. GOKU]
MTDKMKEMLKFAQEMEVAGITDGESARRIAARIKAKELKERYAHLTPMSGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLNLIDNKAISI

Download         Length: 321 bp

>AT115244 NZ_CP034105:3840078-3840398 [Proteus sp. GOKU]
ATGACTGATAAAATGAAAGAAATGCTGAAATTTGCACAAGAAATGGAAGTTGCGGGAATAACCGATGGAGAATCGGCTAG
ACGAATTGCAGCCAGAATAAAAGCCAAAGAATTAAAAGAAAGATATGCTCACCTGACTCCAATGAGTGGTGAAGATATAA
AAAGAATTCGCGAGCAAAATAACATTTCGCAATCGTCTCTTGCTTTAATACTAAATATGACAAAAGAGAGTGTATCAAAA
TGGGAGCGGAACGAAATTAAACCCAACGGAGCAGCACTGAGACTTTTGAATTTAATAGATAATAAAGCAATTTCAATCTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References