Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 522451..523247 Replicon chromosome
Accession NZ_CP034105
Organism Proteus sp. GOKU

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag EHE21_RS02500 Protein ID WP_194951755.1
Coordinates 522735..523247 (+) Length 171 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag EHE21_RS02495 Protein ID WP_194951754.1
Coordinates 522451..522738 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHE21_RS02475 518066..518731 + 666 WP_023583735.1 cell division ATP-binding protein FtsE -
EHE21_RS02480 518724..519701 + 978 WP_194951752.1 permease-like cell division protein FtsX -
EHE21_RS02485 520067..520921 + 855 WP_023583733.1 RNA polymerase sigma factor RpoH -
EHE21_RS02490 521016..522155 + 1140 WP_194951753.1 glycerate kinase -
EHE21_RS02495 522451..522738 + 288 WP_194951754.1 DUF1778 domain-containing protein Antitoxin
EHE21_RS02500 522735..523247 + 513 WP_194951755.1 GNAT family N-acetyltransferase Toxin
EHE21_RS02505 523352..523759 - 408 WP_194951756.1 aspartate 1-decarboxylase autocleavage activator PanM -
EHE21_RS02510 523759..524958 - 1200 WP_194951757.1 MFS transporter -
EHE21_RS02515 525078..525545 + 468 WP_194951758.1 MarR family transcriptional regulator -
EHE21_RS02520 525599..526351 - 753 WP_088493840.1 M48 family metallopeptidase -
EHE21_RS02525 526847..527947 - 1101 WP_194951759.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-147)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18391.32 Da        Isoelectric Point: 9.5976

>T115237 WP_194951755.1 NZ_CP034105:522735-523247 [Proteus sp. GOKU]
MTLKLTAPEPLKTSHLLEGFSSGEEALDLWLKNRAMSNQNSGASRTFVTTSDNQVMGYYALSTGVISTNQAVGRFRRNMP
TDIPVILLGRLAVDTRAKGLGIGRGLVKDACHRVIQASGLVGIRGVVVHALTDDAKRFYEHIGFVPSPLDPMMLMVTLAD
LQLAMGIHSN

Download         Length: 513 bp

>T115237 NZ_CP034105:522735-523247 [Proteus sp. GOKU]
ATGACATTGAAACTGACTGCACCTGAACCTCTCAAAACCAGCCATTTGCTGGAAGGCTTTTCCTCCGGTGAAGAGGCCTT
AGATCTCTGGCTAAAAAACAGGGCGATGAGTAATCAAAACTCTGGAGCATCGCGTACTTTTGTGACCACTTCGGATAATC
AGGTAATGGGATATTATGCCTTATCCACAGGAGTCATAAGCACGAATCAAGCTGTTGGTCGATTCCGCCGTAATATGCCC
ACCGACATTCCAGTCATTCTTCTCGGCAGACTAGCAGTGGATACAAGAGCAAAAGGGCTTGGGATTGGAAGAGGGCTGGT
CAAAGATGCCTGTCATCGTGTTATTCAGGCTTCTGGGCTGGTGGGCATTCGAGGAGTAGTAGTCCATGCTCTAACTGATG
ATGCTAAGCGGTTCTATGAGCATATTGGTTTCGTCCCTTCACCGCTTGACCCCATGATGCTGATGGTAACGCTTGCCGAT
CTGCAACTCGCAATGGGTATTCACTCAAACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10695.27 Da        Isoelectric Point: 9.7653

>AT115237 WP_194951754.1 NZ_CP034105:522451-522738 [Proteus sp. GOKU]
MPTQNDVPATRSSLNLRIKPEDKILIDRAANAVGKNRTEFILEAARRAAEETLADLRVINVSPEVYQKFINQLDATPVSN
EALKKTMMSKSPWEK

Download         Length: 288 bp

>AT115237 NZ_CP034105:522451-522738 [Proteus sp. GOKU]
ATGCCAACTCAAAATGATGTGCCTGCAACACGTTCATCACTGAACCTGAGAATAAAACCGGAAGATAAAATCCTGATCGA
CCGCGCAGCGAATGCTGTGGGAAAAAACCGTACTGAATTTATCCTTGAAGCCGCTCGGCGTGCTGCTGAAGAAACACTGG
CGGATCTGCGAGTGATTAACGTCAGCCCTGAGGTATACCAGAAGTTTATTAACCAGCTTGATGCCACGCCCGTTAGCAAT
GAGGCATTGAAGAAAACGATGATGTCTAAATCCCCTTGGGAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References