Detailed information of TA system TA115237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 522451..523247
• Replicon: chromosome
• Accession: NZ_CP034105
• Organism: Proteus sp. GOKU

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: EHE21_RS02500
• Protein ID: WP_194951755.1
• Coordinates: 522735..523247 (+)
• Length: 171 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: EHE21_RS02495
• Protein ID: WP_194951754.1
• Coordinates: 522451..522738 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHE21_RS02475	518066..518731	+	666	WP_023583735.1	cell division ATP-binding protein FtsE	-
EHE21_RS02480	518724..519701	+	978	WP_194951752.1	permease-like cell division protein FtsX	-
EHE21_RS02485	520067..520921	+	855	WP_023583733.1	RNA polymerase sigma factor RpoH	-
EHE21_RS02490	521016..522155	+	1140	WP_194951753.1	glycerate kinase	-
EHE21_RS02495	522451..522738	+	288	WP_194951754.1	DUF1778 domain-containing protein	Antitoxin
EHE21_RS02500	522735..523247	+	513	WP_194951755.1	GNAT family N-acetyltransferase	Toxin
EHE21_RS02505	523352..523759	-	408	WP_194951756.1	aspartate 1-decarboxylase autocleavage activator PanM	-
EHE21_RS02510	523759..524958	-	1200	WP_194951757.1	MFS transporter	-
EHE21_RS02515	525078..525545	+	468	WP_194951758.1	MarR family transcriptional regulator	-
EHE21_RS02520	525599..526351	-	753	WP_088493840.1	M48 family metallopeptidase	-
EHE21_RS02525	526847..527947	-	1101	WP_194951759.1	sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (32-147)

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 171 a.a.
• Molecular weight: 18391.32 Da
• Isoelectric Point: 9.5976

>T115237 WP_194951755.1 NZ_CP034105:522735-523247 [Proteus sp. GOKU]
MTLKLTAPEPLKTSHLLEGFSSGEEALDLWLKNRAMSNQNSGASRTFVTTSDNQVMGYYALSTGVISTNQAVGRFRRNMP
TDIPVILLGRLAVDTRAKGLGIGRGLVKDACHRVIQASGLVGIRGVVVHALTDDAKRFYEHIGFVPSPLDPMMLMVTLAD
LQLAMGIHSN

Nucleotide

• Length: 513 bp

>T115237 NZ_CP034105:522735-523247 [Proteus sp. GOKU]
ATGACATTGAAACTGACTGCACCTGAACCTCTCAAAACCAGCCATTTGCTGGAAGGCTTTTCCTCCGGTGAAGAGGCCTT
AGATCTCTGGCTAAAAAACAGGGCGATGAGTAATCAAAACTCTGGAGCATCGCGTACTTTTGTGACCACTTCGGATAATC
AGGTAATGGGATATTATGCCTTATCCACAGGAGTCATAAGCACGAATCAAGCTGTTGGTCGATTCCGCCGTAATATGCCC
ACCGACATTCCAGTCATTCTTCTCGGCAGACTAGCAGTGGATACAAGAGCAAAAGGGCTTGGGATTGGAAGAGGGCTGGT
CAAAGATGCCTGTCATCGTGTTATTCAGGCTTCTGGGCTGGTGGGCATTCGAGGAGTAGTAGTCCATGCTCTAACTGATG
ATGCTAAGCGGTTCTATGAGCATATTGGTTTCGTCCCTTCACCGCTTGACCCCATGATGCTGATGGTAACGCTTGCCGAT
CTGCAACTCGCAATGGGTATTCACTCAAACTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10695.27 Da
• Isoelectric Point: 9.7653

>AT115237 WP_194951754.1 NZ_CP034105:522451-522738 [Proteus sp. GOKU]
MPTQNDVPATRSSLNLRIKPEDKILIDRAANAVGKNRTEFILEAARRAAEETLADLRVINVSPEVYQKFINQLDATPVSN
EALKKTMMSKSPWEK

Nucleotide

• Length: 288 bp

>AT115237 NZ_CP034105:522451-522738 [Proteus sp. GOKU]
ATGCCAACTCAAAATGATGTGCCTGCAACACGTTCATCACTGAACCTGAGAATAAAACCGGAAGATAAAATCCTGATCGA
CCGCGCAGCGAATGCTGTGGGAAAAAACCGTACTGAATTTATCCTTGAAGCCGCTCGGCGTGCTGCTGAAGAAACACTGG
CGGATCTGCGAGTGATTAACGTCAGCCCTGAGGTATACCAGAAGTTTATTAACCAGCTTGATGCCACGCCCGTTAGCAAT
GAGGCATTGAAGAAAACGATGATGTCTAAATCCCCTTGGGAGAAATGA