Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsdAT/-
Location 2207327..2207841 Replicon chromosome
Accession NZ_CP034102
Organism Staphylococcus aureus strain O267

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag SaO267_RS11640 Protein ID WP_000581796.1
Coordinates 2207327..2207536 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag SaO267_RS11645 Protein ID WP_000138932.1
Coordinates 2207548..2207841 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO267_RS11620 2202832..2204190 - 1359 WP_000611455.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SaO267_RS11625 2204205..2205275 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
SaO267_RS11630 2205593..2206795 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SaO267_RS11635 2207062..2207199 - 138 WP_000828354.1 hypothetical protein -
SaO267_RS11640 2207327..2207536 - 210 WP_000581796.1 heavy-metal-associated domain-containing protein Toxin
SaO267_RS11645 2207548..2207841 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
SaO267_RS11650 2208007..2209491 + 1485 WP_000571549.1 cardiolipin synthase -
SaO267_RS11655 2209519..2210166 + 648 WP_001187615.1 HD domain-containing protein -
SaO267_RS11670 2210903..2211775 - 873 WP_126117052.1 membrane protein insertase YidC -
SaO267_RS11675 2211861..2212502 - 642 WP_000483160.1 thiamine phosphate synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 70 a.a.        Molecular weight: 7859.77 Da        Isoelectric Point: 4.1008

>T115229 WP_000581796.1 NZ_CP034102:c2207536-2207327 [Staphylococcus aureus]
MIHQNTIYTSGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T115229 NZ_CP034102:c2207536-2207327 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACATCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT115229 WP_000138932.1 NZ_CP034102:c2207841-2207548 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT115229 NZ_CP034102:c2207841-2207548 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References