Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 883648..884125 Replicon chromosome
Accession NZ_CP034102
Organism Staphylococcus aureus strain O267

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SaO267_RS04510 Protein ID WP_000052076.1
Coordinates 883648..883836 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SaO267_RS04515 Protein ID WP_001059690.1
Coordinates 883865..884125 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO267_RS04480 879631..880156 + 526 Protein_834 hypothetical protein -
SaO267_RS04485 880497..881183 + 687 WP_126116976.1 thermonuclease family protein -
SaO267_RS04490 881540..881740 + 201 WP_001059082.1 cold-shock protein -
SaO267_RS04495 882239..882457 - 219 WP_000005880.1 hypothetical protein -
SaO267_RS04500 882519..882803 - 285 WP_001004402.1 hypothetical protein -
SaO267_RS04505 882891..883460 - 570 WP_001106650.1 hypothetical protein -
SaO267_RS04510 883648..883836 - 189 WP_000052076.1 hypothetical protein Toxin
SaO267_RS04515 883865..884125 - 261 WP_001059690.1 hypothetical protein Antitoxin
SaO267_RS04520 884466..884669 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SaO267_RS04525 884666..884902 - 237 WP_000368687.1 hypothetical protein -
SaO267_RS04530 885127..885708 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SaO267_RS04535 885781..886398 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
SaO267_RS04540 886554..887048 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SaO267_RS04545 887447..887869 - 423 WP_000974462.1 organic hydroperoxide resistance protein -
SaO267_RS04550 888017..888733 + 717 WP_126116977.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-66)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T115224 WP_000052076.1 NZ_CP034102:c883836-883648 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T115224 NZ_CP034102:c883836-883648 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT115224 WP_001059690.1 NZ_CP034102:c884125-883865 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT115224 NZ_CP034102:c884125-883865 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References