Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2064463..2064977 Replicon chromosome
Accession NZ_CP034098
Organism Staphylococcus aureus strain 80wphwpl_v1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag EHS18_RS10340 Protein ID WP_000581791.1
Coordinates 2064463..2064672 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag EHS18_RS10345 Protein ID WP_000138934.1
Coordinates 2064684..2064977 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHS18_RS10315 2059820..2061022 + 1203 WP_001109940.1 rod shape-determining protein RodA -
EHS18_RS10320 2061183..2061392 - 210 Protein_1921 transposase -
EHS18_RS10325 2061454..2063100 - 1647 WP_000277709.1 IS1182-like element ISSau3 family transposase -
EHS18_RS10330 2063377..2063786 - 410 Protein_1923 transposase -
EHS18_RS10335 2064198..2064335 - 138 WP_000828354.1 hypothetical protein -
EHS18_RS10340 2064463..2064672 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
EHS18_RS10345 2064684..2064977 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
EHS18_RS10350 2065143..2066627 + 1485 WP_000571560.1 cardiolipin synthase -
EHS18_RS10355 2066655..2067302 + 648 WP_001187612.1 HD domain-containing protein -
EHS18_RS10370 2067917..2068789 - 873 WP_000725802.1 membrane protein insertase YidC -
EHS18_RS10375 2068875..2069516 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T115212 WP_000581791.1 NZ_CP034098:c2064672-2064463 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T115212 NZ_CP034098:c2064672-2064463 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT115212 WP_000138934.1 NZ_CP034098:c2064977-2064684 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT115212 NZ_CP034098:c2064977-2064684 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References