Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 802238..802715 Replicon chromosome
Accession NZ_CP034098
Organism Staphylococcus aureus strain 80wphwpl_v1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag EHS18_RS03880 Protein ID WP_000052076.1
Coordinates 802238..802426 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EHS18_RS03885 Protein ID WP_001059690.1
Coordinates 802455..802715 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHS18_RS03850 798191..798748 + 558 WP_000824491.1 hypothetical protein -
EHS18_RS03855 799089..799775 + 687 WP_001574556.1 thermonuclease family protein -
EHS18_RS03860 800132..800332 + 201 WP_001059082.1 cold-shock protein -
EHS18_RS03865 800829..801047 - 219 WP_000005879.1 hypothetical protein -
EHS18_RS03870 801109..801393 - 285 WP_001004401.1 hypothetical protein -
EHS18_RS03875 801481..802050 - 570 WP_001106663.1 hypothetical protein -
EHS18_RS03880 802238..802426 - 189 WP_000052076.1 hypothetical protein Toxin
EHS18_RS03885 802455..802715 - 261 WP_001059690.1 hypothetical protein Antitoxin
EHS18_RS03890 803056..803259 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EHS18_RS03895 803256..803492 - 237 WP_000368687.1 hypothetical protein -
EHS18_RS03900 803717..804298 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
EHS18_RS03905 804371..804988 - 618 WP_000255542.1 LysE/ArgO family amino acid transporter -
EHS18_RS03910 805144..805638 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EHS18_RS03915 806037..806459 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
EHS18_RS03920 806607..807323 + 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 796835..830362 33527


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T115207 WP_000052076.1 NZ_CP034098:c802426-802238 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T115207 NZ_CP034098:c802426-802238 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT115207 WP_001059690.1 NZ_CP034098:c802715-802455 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT115207 NZ_CP034098:c802715-802455 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References