Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 3622..4268 Replicon plasmid pA52-OXA-72
Accession NZ_CP034097
Organism Acinetobacter baumannii strain A52

Toxin (Protein)


Gene name vapC Uniprot ID A0A6G6AQI7
Locus tag EHF38_RS19430 Protein ID WP_063099733.1
Coordinates 3861..4268 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G6AR75
Locus tag EHF38_RS19425 Protein ID WP_063099732.1
Coordinates 3622..3861 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHF38_RS19405 1..936 + 936 WP_096641239.1 replication initiation protein RepM -
EHF38_RS19410 1005..1481 + 477 WP_171265043.1 plasmid replication DNA-binding protein -
EHF38_RS19415 1670..2497 - 828 WP_128385935.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase -
EHF38_RS19420 2856..3419 - 564 WP_050660967.1 GNAT family N-acetyltransferase -
EHF38_RS19425 3622..3861 + 240 WP_063099732.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EHF38_RS19430 3861..4268 + 408 WP_063099733.1 type II toxin-antitoxin system VapC family toxin Toxin
EHF38_RS19435 4331..4636 + 306 WP_062911967.1 hypothetical protein -
EHF38_RS19440 4791..5849 + 1059 WP_032007737.1 ParA family protein -
EHF38_RS19500 6059..6220 - 162 WP_155767404.1 hypothetical protein -
EHF38_RS19505 6275..6430 - 156 WP_155767402.1 hypothetical protein -
EHF38_RS19445 6432..6944 - 513 WP_032007735.1 hypothetical protein -
EHF38_RS19450 7161..7352 - 192 WP_032007734.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-72 - 1..8493 8493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(8-53)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15312.65 Da        Isoelectric Point: 6.2815

>T115206 WP_063099733.1 NZ_CP034097:3861-4268 [Acinetobacter baumannii]
MEYLLDTNIVGYLLQGVASNKLKNKLMMVNPDSVFISQITHAEIVYGLEKGGNIPKHIDRVNSFLETLSILDWDDQCAHA
YGKVRNELRLQGVTVQSMDLMIGAHALGHHLILVSNDHIFDHFKQFGLVLENWQI

Download         Length: 408 bp

>T115206 NZ_CP034097:3861-4268 [Acinetobacter baumannii]
ATGGAATATCTACTTGATACAAATATCGTGGGCTATCTTTTACAAGGTGTTGCCAGTAATAAGCTGAAGAACAAGCTGAT
GATGGTTAATCCTGATAGTGTATTTATTTCACAGATTACTCATGCTGAGATTGTTTATGGCCTAGAAAAAGGTGGGAATA
TTCCCAAGCATATTGATCGTGTAAACTCTTTTTTAGAAACCTTAAGTATTTTAGATTGGGATGATCAGTGCGCTCATGCT
TACGGCAAGGTTCGTAATGAATTACGTCTACAGGGTGTCACTGTACAGTCAATGGATTTGATGATTGGTGCTCATGCACT
TGGTCATCATCTTATTTTAGTCAGCAATGATCATATTTTTGATCATTTCAAACAATTTGGACTAGTTTTAGAAAACTGGC
AAATTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9360.58 Da        Isoelectric Point: 5.8451

>AT115206 WP_063099732.1 NZ_CP034097:3622-3861 [Acinetobacter baumannii]
MNHTAKVFMNGQSQAVRLPKQFRFESKTVYVRRNTKGEVILSEKPRTWADFFEENTDMSGFETLMADREQDIPIERDIF

Download         Length: 240 bp

>AT115206 NZ_CP034097:3622-3861 [Acinetobacter baumannii]
ATGAATCATACCGCAAAAGTTTTTATGAATGGTCAAAGCCAAGCAGTACGCCTGCCGAAACAATTTCGTTTTGAAAGCAA
AACTGTTTATGTCAGACGAAATACTAAAGGTGAAGTAATCCTTTCTGAAAAACCTCGGACATGGGCTGATTTTTTTGAGG
AAAATACTGATATGTCAGGATTTGAGACATTAATGGCTGATCGTGAACAGGACATACCAATTGAACGAGATATTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6AQI7

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6AR75

References