Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 16441..16969 Replicon plasmid pA52-2
Accession NZ_CP034094
Organism Acinetobacter baumannii strain A52

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag EHF38_RS19265 Protein ID WP_000221358.1
Coordinates 16676..16969 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag EHF38_RS19260 Protein ID WP_000246756.1
Coordinates 16441..16686 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHF38_RS19225 12855..13496 + 642 WP_000585008.1 AAA family ATPase -
EHF38_RS19230 13497..13787 + 291 WP_001185414.1 hypothetical protein -
EHF38_RS19245 15099..15802 + 704 Protein_16 IS6-like element IS1008 family transposase -
EHF38_RS19260 16441..16686 + 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EHF38_RS19265 16676..16969 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHF38_RS19270 17133..18083 + 951 WP_128385926.1 DUF4062 domain-containing protein -
EHF38_RS19665 18316..18477 - 162 WP_213075440.1 hypothetical protein -
EHF38_RS19275 18461..19090 - 630 WP_128385927.1 hypothetical protein -
EHF38_RS19280 19209..19418 - 210 WP_000069472.1 hypothetical protein -
EHF38_RS19285 19411..19713 - 303 WP_001140621.1 XRE family transcriptional regulator -
EHF38_RS19290 19706..20062 - 357 WP_000269909.1 type II toxin-antitoxin system RelE/ParE family toxin -
EHF38_RS19295 20683..21372 + 690 WP_128385928.1 hypothetical protein -
EHF38_RS19300 21638..21946 - 309 WP_000244382.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..27452 27452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T115204 WP_000221358.1 NZ_CP034094:16676-16969 [Acinetobacter baumannii]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T115204 NZ_CP034094:16676-16969 [Acinetobacter baumannii]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGCATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT115204 WP_000246756.1 NZ_CP034094:16441-16686 [Acinetobacter baumannii]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT115204 NZ_CP034094:16441-16686 [Acinetobacter baumannii]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAATTGCCTGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References