Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1838874..1840510 Replicon chromosome
Accession NZ_CP034092
Organism Acinetobacter baumannii strain A52

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EHF38_RS08875 Protein ID WP_104159495.1
Coordinates 1838874..1840205 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EHF38_RS08880 Protein ID WP_001101308.1
Coordinates 1840202..1840510 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHF38_RS08855 1835189..1836349 + 1161 WP_001044492.1 hypothetical protein -
EHF38_RS08860 1836476..1837447 + 972 WP_128385765.1 acid phosphatase -
EHF38_RS08865 1837459..1838103 + 645 WP_000817301.1 hypothetical protein -
EHF38_RS08870 1838138..1838578 - 441 WP_000193135.1 HD domain-containing protein -
EHF38_RS08875 1838874..1840205 + 1332 WP_104159495.1 type II toxin-antitoxin system HipA family toxin Toxin
EHF38_RS08880 1840202..1840510 + 309 WP_001101308.1 helix-turn-helix domain-containing protein Antitoxin
EHF38_RS08885 1840894..1841793 - 900 Protein_1715 IS3 family transposase -
EHF38_RS08890 1841769..1842278 - 510 WP_001145037.1 helix-turn-helix domain-containing protein -
EHF38_RS08895 1842703..1843254 + 552 WP_104159496.1 TetR/AcrR family transcriptional regulator -
EHF38_RS08900 1843470..1844090 + 621 WP_000658761.1 hypothetical protein -
EHF38_RS08905 1844108..1845190 + 1083 WP_001095788.1 ImmA/IrrE family metallo-endopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51205.16 Da        Isoelectric Point: 4.7456

>T115203 WP_104159495.1 NZ_CP034092:1838874-1840205 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLSTLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T115203 NZ_CP034092:1838874-1840205 [Acinetobacter baumannii]
ATGAAAAAATTAACGATACAAGCTTTACTAAATAAAAACTGGATAGATATAGCAGAGCTAAAACTGTTAGAACCTAAGTT
GGGTTCGGCTAGCGCCAGTGAACTAGAATATGAATTGGATTATGCAATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACACGAATCGGATACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGGATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTGCCTCCACTAAACCCAGAGTCAACCTTGC
ACTTACGTTATTTTAGTAAGGAAGATGTGGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCTATT
AGTGGTGGTGCAACTGGTGCAGGCGGTGAAGCTCCCAAGTTGCTTATTCGTGTTTCACCGGAACAAAAAGTCTGGATTGA
CACCTACCAAGAACAATTTGATCAGCCAGATCAGCATTATTTAGTTAAATTTCCGCGAAATAATCGTAGCGAGATTGATT
GCGATATTCTCAGAGCTGAATATTATTACTATCAAATACTCAATGAGTTAGGTTTCAATACGATAGAGACGACTCAAATG
CAGCTTATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTCGAAGTCATTGAAGATC
TATGTAGATTACTCACAAGCATTGACTCAGATTTTGATGTACCACAATTTATTTGTGAGTGGTTACAACGCGACTTACTC
AATATCATTTTTGGCAATTCAGATAACCACGGTCGGAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCAGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTATGAGGAAG
GAGGTGAATACCGGTGGGCACAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTATCAACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAACGATTAGTTGATAAAGGTGTACCAAAACAAATTATTGAAATGCCAGC
GCTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.55 Da        Isoelectric Point: 9.9701

>AT115203 WP_001101308.1 NZ_CP034092:1840202-1840510 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp

>AT115203 NZ_CP034092:1840202-1840510 [Acinetobacter baumannii]
ATGAATGTAAAAAATCAACCCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTATCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTGTTTAAACCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References