Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 456833..457486 Replicon chromosome
Accession NZ_CP034092
Organism Acinetobacter baumannii strain A52

Toxin (Protein)


Gene name cptA Uniprot ID A0A5N0FZY3
Locus tag EHF38_RS02255 Protein ID WP_000607074.1
Coordinates 457097..457486 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag EHF38_RS02250 Protein ID WP_001288210.1
Coordinates 456833..457090 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHF38_RS02230 452349..453356 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
EHF38_RS02235 453375..453752 + 378 WP_001216380.1 50S ribosomal protein L17 -
EHF38_RS02240 453933..455423 + 1491 WP_104159628.1 NAD(P)/FAD-dependent oxidoreductase -
EHF38_RS02245 455473..456645 - 1173 WP_001190545.1 acyl-CoA dehydrogenase family protein -
EHF38_RS02250 456833..457090 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
EHF38_RS02255 457097..457486 + 390 WP_000607074.1 membrane protein Toxin
EHF38_RS02260 458256..459341 + 1086 WP_000049106.1 hypothetical protein -
EHF38_RS02265 459419..459985 + 567 WP_000651536.1 rhombosortase -
EHF38_RS02270 460173..462368 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15621.89 Da        Isoelectric Point: 10.3890

>T115202 WP_000607074.1 NZ_CP034092:457097-457486 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T115202 NZ_CP034092:457097-457486 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT115202 WP_001288210.1 NZ_CP034092:456833-457090 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT115202 NZ_CP034092:456833-457090 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5N0FZY3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References