115201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3377500..3379229 Replicon chromosome
Accession NZ_CP034091
Organism Proteus mirabilis strain PmBC1123

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EHQ66_RS15845 Protein ID WP_124743833.1
Coordinates 3377500..3378870 (+) Length 457 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EHQ66_RS15850 Protein ID WP_060556489.1
Coordinates 3378867..3379229 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHQ66_RS15830 3373161..3374144 - 984 WP_060556493.1 ABC transporter permease -
EHQ66_RS15835 3374129..3375712 - 1584 WP_107034445.1 ABC transporter substrate-binding protein -
EHQ66_RS15840 3376113..3377105 - 993 WP_060556491.1 glycosyltransferase -
EHQ66_RS15845 3377500..3378870 + 1371 WP_124743833.1 type II toxin-antitoxin system HipA family toxin Toxin
EHQ66_RS15850 3378867..3379229 + 363 WP_060556489.1 helix-turn-helix domain-containing protein Antitoxin
EHQ66_RS15855 3379369..3379857 - 489 WP_071524522.1 hydrogenase maturation peptidase HycI -
EHQ66_RS15860 3379866..3380276 - 411 WP_004245685.1 formate hydrogenlyase maturation HycH family protein -
EHQ66_RS15865 3380269..3381051 - 783 WP_060556488.1 NADH-quinone oxidoreductase subunit B family protein -
EHQ66_RS15870 3381048..3381602 - 555 WP_004245688.1 hydrogenase 4 subunit H -
EHQ66_RS15875 3381614..3383347 - 1734 WP_060556487.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(J) / aadA2 / ere(A) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aph(3')-Ia / tet(C) / sul2 / aph(3'')-Ib / aph(6)-Id / floR - 3172359..3401945 229586


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-415)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-101)


Sequences

Toxin        


Download         Length: 457 a.a.        Molecular weight: 52554.44 Da        Isoelectric Point: 4.7349

>T115201 WP_124743833.1 NZ_CP034091:3377500-3378870 [Proteus mirabilis]
MEKITLQAFLNQEWRDIAIINFPNDEHLALENQYDITYPITELAYESDYSIDYLFRDDHHAVSLNHPVSLFFDDKGSPGW
FKFLDDIVPSGASRRYWVQYLDIAGLSIAQQNYQLLRNGTISPIGNLRVKESLPHLSTLNNDLFFTIDEVKNRSSDFLEY
AQRKGAAAGGATGAGGEAPKLLLRCSHDEKIWIDTYQNDISNHDRYYLVKFPRGRRTSVDCNILRTEYAFYHELTAMGFN
TIPIEGMRLEEGDNYPSLWLPRFDIQIENNQVIRLAMESVYSILNKASGTTLYHEAVIREIIEKINQSNMVTEFGFQFNI
TNFIIEWVRRDLLNIIFGNSDNHGRNTSFIRKDNAIYLAPIYDFAPMKADPEGIVRTTKWQSYEMGGEFDFIGIANSLAD
LIPQEQLLEALRETALQLLDLKERLKERGVPEQILTMPTFGFDFIPDKLARWGLLP

Download         Length: 1371 bp

>T115201 NZ_CP034091:3377500-3378870 [Proteus mirabilis]
ATGGAAAAGATAACGTTACAAGCTTTTCTCAATCAAGAATGGAGAGATATTGCCATCATAAATTTTCCTAATGATGAACA
CCTAGCATTAGAAAACCAATATGATATCACTTATCCAATAACTGAACTTGCTTATGAAAGTGACTATTCAATAGATTATT
TATTTCGCGATGATCACCATGCTGTTTCTCTTAACCATCCTGTTTCTTTGTTTTTTGATGATAAAGGTTCACCCGGTTGG
TTTAAGTTTTTAGATGATATTGTTCCCAGTGGTGCTAGTCGAAGATATTGGGTTCAATATCTTGATATTGCTGGGCTATC
TATTGCACAACAAAATTATCAATTATTACGTAATGGTACTATTTCTCCTATTGGTAATTTACGGGTAAAAGAATCATTAC
CTCATCTATCTACTTTAAATAACGATCTTTTTTTTACTATTGATGAGGTTAAGAACCGCTCAAGTGATTTCCTAGAATAT
GCGCAACGAAAAGGAGCTGCTGCAGGTGGTGCAACAGGGGCTGGTGGTGAGGCACCTAAATTATTATTAAGATGTAGTCA
TGATGAAAAGATTTGGATTGATACATATCAAAATGATATTTCTAATCATGATCGTTACTATTTAGTAAAATTCCCTAGGG
GACGTCGAACAAGTGTAGACTGCAATATTCTAAGAACTGAATACGCTTTTTATCATGAACTTACTGCTATGGGATTTAAT
ACTATTCCCATCGAAGGGATGCGCTTAGAAGAAGGAGATAACTATCCTTCTTTATGGTTGCCTCGTTTTGATATCCAAAT
AGAAAATAATCAAGTTATTCGCTTAGCAATGGAATCTGTCTATTCGATATTAAACAAAGCATCAGGTACTACGTTATATC
ATGAAGCCGTTATTAGAGAGATAATTGAAAAAATTAATCAAAGTAATATGGTAACCGAATTTGGTTTCCAATTTAATATC
ACTAACTTTATCATTGAATGGGTTAGACGTGATCTACTAAATATTATCTTTGGCAATAGTGATAACCATGGTCGTAATAC
CTCTTTTATAAGAAAAGATAACGCTATTTATCTAGCGCCTATTTATGACTTCGCACCTATGAAAGCAGATCCTGAAGGAA
TAGTTAGAACAACAAAATGGCAATCTTATGAAATGGGAGGAGAATTTGATTTTATTGGTATTGCAAACTCTCTAGCTGAT
TTAATTCCTCAAGAACAGTTACTCGAAGCCTTAAGGGAAACTGCATTACAACTACTCGATTTAAAAGAAAGATTAAAAGA
ACGAGGGGTGCCAGAACAAATTCTAACAATGCCTACATTTGGCTTTGATTTTATACCTGATAAGCTAGCACGCTGGGGAT
TGTTACCATGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13542.07 Da        Isoelectric Point: 10.6882

>AT115201 WP_060556489.1 NZ_CP034091:3378867-3379229 [Proteus mirabilis]
MNNIDNKITKLPLRASNNRSLIATIDRKKTIEKIMLSLLLEEISQGKALKILRLNILGLKQDAYAKLVNISRKTLSDIEN
DKGNYSIDIINKAFKPFGLKIGLVPATSHMLLSILKNHYQ

Download         Length: 363 bp

>AT115201 NZ_CP034091:3378867-3379229 [Proteus mirabilis]
ATGAATAATATTGACAACAAGATAACTAAATTACCTTTAAGAGCATCAAATAACCGCTCATTAATTGCTACTATTGATAG
AAAAAAAACGATTGAAAAAATCATGCTGAGCTTATTACTTGAAGAAATTTCCCAAGGAAAAGCATTAAAAATATTAAGAC
TCAATATTCTCGGTTTAAAACAAGATGCCTATGCTAAATTAGTTAATATTTCACGTAAGACACTATCTGATATAGAAAAT
GATAAGGGGAATTACTCTATTGATATTATTAATAAAGCTTTTAAACCTTTTGGATTAAAAATAGGATTGGTTCCAGCAAC
TAGTCATATGTTGCTATCAATACTAAAAAACCATTACCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References