Detailed information of TA system TA115197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3684954..3685653
• Replicon: chromosome
• Accession: NZ_CP034090
• Organism: Proteus mirabilis strain PmSC1111

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: EHQ78_RS17175
• Protein ID: WP_004249093.1
• Coordinates: 3685267..3685653 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: EHQ78_RS17170
• Protein ID: WP_004246828.1
• Coordinates: 3684954..3685274 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHQ78_RS17140	3680083..3680358	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
EHQ78_RS17145	3680413..3681036	-	624	WP_004246821.1	guanylate kinase	-
EHQ78_RS17150	3681338..3681955	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
EHQ78_RS17155	3682092..3683378	+	1287	WP_017827115.1	DUF3748 domain-containing protein	-
EHQ78_RS17160	3683593..3684474	+	882	WP_063108821.1	endonuclease/exonuclease/phosphatase family protein	-
EHQ78_RS17165	3684471..3684905	+	435	WP_020946391.1	hypothetical protein	-
EHQ78_RS17170	3684954..3685274	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
EHQ78_RS17175	3685267..3685653	-	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHQ78_RS17180	3685815..3687887	-	2073	WP_041701373.1	glycine--tRNA ligase subunit beta	-
EHQ78_RS17185	3687897..3688802	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
EHQ78_RS17190	3689053..3689634	+	582	WP_004246833.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T115197 WP_004249093.1 NZ_CP034090:c3685653-3685267 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T115197 NZ_CP034090:c3685653-3685267 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATTGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT115197 WP_004246828.1 NZ_CP034090:c3685274-3684954 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT115197 NZ_CP034090:c3685274-3684954 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCCTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCCGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97