Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3267696..3268297 Replicon chromosome
Accession NZ_CP034090
Organism Proteus mirabilis strain PmSC1111

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag EHQ78_RS15175 Protein ID WP_004246497.1
Coordinates 3267914..3268297 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag EHQ78_RS15170 Protein ID WP_004246496.1
Coordinates 3267696..3267917 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHQ78_RS15145 3263481..3263939 + 459 WP_004246490.1 dUTP diphosphatase -
EHQ78_RS15150 3264059..3264664 + 606 WP_004246491.1 nucleoid occlusion factor SlmA -
EHQ78_RS15155 3264983..3265627 - 645 WP_004246493.1 orotate phosphoribosyltransferase -
EHQ78_RS15160 3265709..3266425 - 717 WP_004249760.1 ribonuclease PH -
EHQ78_RS15165 3266552..3267415 + 864 WP_004249947.1 YicC family protein -
EHQ78_RS15170 3267696..3267917 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EHQ78_RS15175 3267914..3268297 + 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
EHQ78_RS15180 3268703..3269017 + 315 WP_004246498.1 helix-turn-helix domain-containing protein -
EHQ78_RS15185 3269030..3270268 + 1239 WP_020946511.1 HipA domain-containing protein -
EHQ78_RS15190 3270625..3271524 - 900 WP_063108742.1 N-acetylmuramic acid 6-phosphate etherase -
EHQ78_RS15195 3271633..3272370 + 738 WP_004249950.1 sel1 repeat family protein -
EHQ78_RS15200 3272466..3272924 - 459 WP_004249766.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T115196 WP_004246497.1 NZ_CP034090:3267914-3268297 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T115196 NZ_CP034090:3267914-3268297 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT115196 WP_004246496.1 NZ_CP034090:3267696-3267917 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT115196 NZ_CP034090:3267696-3267917 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References