Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1058573..1059288 Replicon chromosome
Accession NZ_CP034086
Organism Methylocystis rosea strain GW6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EHO51_RS05035 Protein ID WP_124737976.1
Coordinates 1058573..1058995 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EHO51_RS05040 Protein ID WP_109025442.1
Coordinates 1058992..1059288 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHO51_RS05005 1053928..1054596 + 669 WP_124737971.1 M15 family metallopeptidase -
EHO51_RS05010 1054889..1055638 + 750 WP_124737972.1 porin family protein -
EHO51_RS05015 1055766..1056641 - 876 WP_124737973.1 lipase family protein -
EHO51_RS05025 1057159..1057674 - 516 WP_124737974.1 dihydrofolate reductase -
EHO51_RS05030 1057681..1058484 - 804 WP_124737975.1 thymidylate synthase -
EHO51_RS05035 1058573..1058995 - 423 WP_124737976.1 type II toxin-antitoxin system VapC family toxin Toxin
EHO51_RS05040 1058992..1059288 - 297 WP_109025442.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EHO51_RS05045 1059430..1060419 + 990 WP_124737977.1 TIM44-like domain-containing protein -
EHO51_RS05050 1060566..1063154 + 2589 WP_124737978.1 ATP-dependent helicase HrpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(20-69)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15996.56 Da        Isoelectric Point: 10.1394

>T115184 WP_124737976.1 NZ_CP034086:c1058995-1058573 [Methylocystis rosea]
VSGWLLDTNVLSELRRPRPNAKVVAFVAAQPLDRLYVSVVTFAEIRFGIELVADPSRRAELHDWLTLKVRPLFTQRTLPV
SEDVMLKWRLLVEEGRKTRYTFSQPDLIIAATALLHGFTVVTRDTGDFEKARAPVINPWQ

Download         Length: 423 bp

>T115184 NZ_CP034086:c1058995-1058573 [Methylocystis rosea]
GTGAGCGGATGGCTGCTCGACACCAATGTGCTTTCGGAACTGCGTCGTCCGAGGCCCAATGCAAAGGTCGTCGCATTCGT
AGCTGCGCAGCCGCTCGATCGGCTCTATGTCAGCGTGGTCACTTTTGCGGAAATCCGCTTTGGAATTGAGCTTGTCGCCG
ACCCTTCGAGACGGGCCGAATTGCACGACTGGCTCACGCTCAAAGTGCGACCGCTGTTTACACAAAGGACGCTGCCGGTT
AGCGAGGATGTCATGTTGAAGTGGCGCCTGCTCGTCGAAGAAGGGCGCAAGACGCGATATACTTTCTCCCAGCCTGATCT
CATCATCGCCGCCACAGCGCTTCTCCACGGCTTCACGGTCGTGACGCGAGATACTGGCGATTTCGAGAAAGCGCGCGCGC
CGGTTATCAATCCGTGGCAATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11077.58 Da        Isoelectric Point: 8.8888

>AT115184 WP_109025442.1 NZ_CP034086:c1059288-1058992 [Methylocystis rosea]
MTRFSKSTHKEPTSPGRWVLQDAKARFSELVRRVRSEGPQHVTVHGRDAVVVVSAEEFRRLEGERTGDALIAAMQASPAR
DIDIEPKREAMPVREIEL

Download         Length: 297 bp

>AT115184 NZ_CP034086:c1059288-1058992 [Methylocystis rosea]
ATGACTAGATTTTCGAAATCGACCCACAAGGAGCCGACTTCACCGGGTCGGTGGGTCCTTCAAGACGCCAAGGCACGCTT
CAGCGAACTGGTGCGGCGCGTCCGCAGCGAAGGGCCTCAGCATGTGACTGTGCACGGACGCGACGCCGTGGTCGTCGTGT
CGGCGGAGGAATTTCGTCGGCTCGAGGGAGAGCGTACGGGGGACGCGTTGATCGCCGCGATGCAGGCGTCGCCCGCGCGC
GACATCGACATTGAGCCCAAACGGGAAGCGATGCCCGTGCGCGAGATCGAATTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References