Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 404077..404799 Replicon chromosome
Accession NZ_CP034086
Organism Methylocystis rosea strain GW6

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EHO51_RS01875 Protein ID WP_205789004.1
Coordinates 404077..404409 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EHO51_RS01880 Protein ID WP_124737460.1
Coordinates 404557..404799 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHO51_RS01850 400140..400793 + 654 WP_029651579.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
EHO51_RS01855 400985..401851 + 867 WP_018407270.1 acetylglutamate kinase -
EHO51_RS01860 402026..402721 + 696 WP_124737456.1 NAD-dependent deacylase -
EHO51_RS01865 402843..403547 + 705 WP_124737457.1 pyrimidine 5'-nucleotidase -
EHO51_RS01870 403544..404053 - 510 WP_124737458.1 DinB family protein -
EHO51_RS01875 404077..404409 - 333 WP_205789004.1 endoribonuclease MazF Toxin
EHO51_RS01880 404557..404799 - 243 WP_124737460.1 PbsX family transcriptional regulator Antitoxin
EHO51_RS01885 405211..406068 + 858 WP_124737461.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
EHO51_RS01890 406068..406541 + 474 WP_124737462.1 hypothetical protein -
EHO51_RS01895 406723..407892 + 1170 WP_124737463.1 succinyl-diaminopimelate desuccinylase -
EHO51_RS01900 407855..408322 - 468 WP_124737464.1 protein tyrosine phosphatase family protein -
EHO51_RS01905 408580..409797 - 1218 WP_124737465.1 LL-diaminopimelate aminotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-105)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12073.24 Da        Isoelectric Point: 10.1594

>T115183 WP_205789004.1 NZ_CP034086:c404409-404077 [Methylocystis rosea]
IEMPYVPERGDIVWLSFDPQAGHEQKGHRPALVLSPKAYNGKTGLMLCCPMTMKIKAYPFEVPLAEAKPSVALADQVKSL
DWRARKAKKKGAATKAEVAEALAKARTLLQ

Download         Length: 333 bp

>T115183 NZ_CP034086:c404409-404077 [Methylocystis rosea]
ATTGAAATGCCTTACGTCCCGGAACGCGGCGATATCGTCTGGCTCAGTTTCGATCCGCAGGCGGGCCATGAACAGAAGGG
CCATCGTCCGGCGCTGGTGCTCAGTCCCAAGGCCTATAACGGCAAGACGGGGTTGATGCTCTGCTGCCCGATGACGATGA
AGATCAAAGCCTATCCATTTGAAGTCCCGCTCGCCGAAGCGAAGCCTTCGGTCGCGCTCGCCGATCAGGTGAAGAGCCTC
GACTGGCGCGCGCGCAAGGCGAAGAAGAAAGGCGCGGCGACGAAAGCGGAAGTGGCGGAGGCTTTGGCGAAGGCAAGGAC
GCTGCTGCAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8829.04 Da        Isoelectric Point: 4.2932

>AT115183 WP_124737460.1 NZ_CP034086:c404799-404557 [Methylocystis rosea]
MRATIRKWGNSAAVRMSAAVMEEARLEIDQPVDVRVEEGRVVIEPLVAPEFTLEALLAGVTRDNLHEEEDFGAPVGREAL

Download         Length: 243 bp

>AT115183 NZ_CP034086:c404799-404557 [Methylocystis rosea]
ATGCGCGCGACCATAAGAAAATGGGGAAATTCTGCCGCCGTGCGCATGTCGGCCGCGGTGATGGAGGAAGCCCGGCTCGA
AATCGACCAGCCGGTCGACGTTCGCGTCGAAGAAGGGCGCGTGGTGATCGAGCCGCTTGTGGCGCCAGAATTCACGCTCG
AGGCGCTGCTCGCAGGCGTCACACGCGACAATCTGCATGAAGAGGAAGACTTCGGCGCGCCTGTCGGCCGCGAGGCGCTT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References