Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4916742..4917258 Replicon chromosome
Accession NZ_CP034082
Organism Klebsiella pneumoniae subsp. pneumoniae strain R210-2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag EHV09_RS24160 Protein ID WP_004178374.1
Coordinates 4916742..4917026 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag EHV09_RS24165 Protein ID WP_002886901.1
Coordinates 4917016..4917258 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHV09_RS24140 4912138..4912446 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
EHV09_RS30755 4912531..4912704 + 174 WP_041169004.1 hypothetical protein -
EHV09_RS24145 4912707..4913450 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
EHV09_RS24150 4913807..4915945 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
EHV09_RS24155 4916274..4916738 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EHV09_RS24160 4916742..4917026 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHV09_RS24165 4917016..4917258 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EHV09_RS24170 4917336..4919246 - 1911 WP_012737231.1 BglG family transcription antiterminator -
EHV09_RS24175 4919269..4920423 - 1155 WP_012737230.1 lactonase family protein -
EHV09_RS24180 4920490..4921230 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T115175 WP_004178374.1 NZ_CP034082:c4917026-4916742 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T115175 NZ_CP034082:c4917026-4916742 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT115175 WP_002886901.1 NZ_CP034082:c4917258-4917016 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT115175 NZ_CP034082:c4917258-4917016 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References