Detailed information of TA system TA115114

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 570097..570721
• Replicon: chromosome
• Accession: NZ_CP034071
• Organism: Helicobacter pylori strain Hpbs1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EHU52_RS02860
• Protein ID: WP_075645685.1
• Coordinates: 570455..570721 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EHU52_RS02855
• Protein ID: WP_124733058.1
• Coordinates: 570097..570474 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHU52_RS02830	565234..566346	+	1113	WP_124733055.1	hydrogenase formation protein HypD	-
EHU52_RS02835	566297..566818	-	522	WP_124733056.1	hypothetical protein	-
EHU52_RS02850	567339..569573	+	2235	WP_124733057.1	Hop family adhesin BabA	-
EHU52_RS02855	570097..570474	+	378	WP_124733058.1	hypothetical protein	Antitoxin
EHU52_RS02860	570455..570721	+	267	WP_075645685.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
EHU52_RS02865	570827..571360	-	534	WP_124733059.1	acyl-CoA thioesterase	-
EHU52_RS02870	571500..572342	+	843	WP_124733060.1	SDR family oxidoreductase	-
EHU52_RS02875	572335..573315	+	981	WP_000921438.1	iron ABC transporter permease	-
EHU52_RS02880	573315..574082	+	768	WP_000242367.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10304.11 Da
• Isoelectric Point: 8.0602

>T115114 WP_075645685.1 NZ_CP034071:570455-570721 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T115114 NZ_CP034071:570455-570721 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCGCTAGATCCCCAATTTAAAGATCATGCTTTAAAAGGCAATTGGA
AACCTTTCAGAGAATGCCATATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTAGTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14690.65 Da
• Isoelectric Point: 7.7778

>AT115114 WP_124733058.1 NZ_CP034071:570097-570474 [Helicobacter pylori]
MPNSPAKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Nucleotide

• Length: 378 bp

>AT115114 NZ_CP034071:570097-570474 [Helicobacter pylori]
ATGCCTAATTCTCCCGCCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAACGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA