Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 4215723..4216207 Replicon chromosome
Accession NZ_CP034067
Organism Shigella sonnei strain FDAARGOS_524

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag EGX92_RS21940 Protein ID WP_014334020.1
Coordinates 4215917..4216207 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag EGX92_RS21935 Protein ID WP_005142544.1
Coordinates 4215723..4215917 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX92_RS21895 (4210918) 4210918..4211274 - 357 WP_005140877.1 hypothetical protein -
EGX92_RS21900 (4211332) 4211332..4211754 - 423 WP_001151171.1 DUF977 family protein -
EGX92_RS21905 (4211770) 4211770..4212495 - 726 WP_000450631.1 DUF1627 domain-containing protein -
EGX92_RS21910 (4212517) 4212517..4213263 - 747 WP_000788740.1 ATP-binding protein -
EGX92_RS21915 (4213270) 4213270..4214334 - 1065 WP_001262380.1 hypothetical protein -
EGX92_RS21920 (4214406) 4214406..4214831 - 426 WP_000693826.1 toxin YdaT family protein -
EGX92_RS21925 (4214828) 4214828..4215091 - 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
EGX92_RS21930 (4215218) 4215218..4215703 + 486 WP_053002468.1 helix-turn-helix domain-containing protein -
EGX92_RS21935 (4215723) 4215723..4215917 + 195 WP_005142544.1 hypothetical protein Antitoxin
EGX92_RS21940 (4215917) 4215917..4216207 + 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGX92_RS21945 (4216488) 4216488..4216640 + 153 WP_000379558.1 DUF1391 family protein -
EGX92_RS21950 (4216652) 4216652..4217017 + 366 WP_024174355.1 hypothetical protein -
EGX92_RS21960 (4217920) 4217920..4218996 + 1077 Protein_4106 molybdopterin dinucleotide binding domain-containing protein -
EGX92_RS21965 (4219007) 4219007..4219624 + 618 WP_000213029.1 dimethylsulfoxide reductase subunit B -
EGX92_RS21970 (4219626) 4219626..4220480 + 855 WP_000526502.1 dimethyl sulfoxide reductase anchor subunit family protein -
EGX92_RS21975 (4220523) 4220523..4221137 + 615 WP_000148710.1 Tat proofreading chaperone DmsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vgrG/tssI / rhs/PAAR / rhs/PAAR / sodB 4080971..4309214 228243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T115105 WP_014334020.1 NZ_CP034067:4215917-4216207 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T115105 NZ_CP034067:4215917-4216207 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT115105 WP_005142544.1 NZ_CP034067:4215723-4215917 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT115105 NZ_CP034067:4215723-4215917 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References