Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 46196..46718 Replicon plasmid unnamed1
Accession NZ_CP034046
Organism Klebsiella pneumoniae strain KP_NORM_BLD_2014_104014

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag EHF42_RS26405 Protein ID WP_004181778.1
Coordinates 46434..46718 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag EHF42_RS26400 Protein ID WP_004181777.1
Coordinates 46196..46444 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHF42_RS26380 41405..42226 - 822 WP_004181772.1 hypothetical protein -
EHF42_RS26385 42288..42641 - 354 WP_004181774.1 hypothetical protein -
EHF42_RS26390 42786..43772 - 987 WP_040120328.1 hypothetical protein -
EHF42_RS26395 44106..45905 - 1800 WP_038991636.1 ATP-dependent helicase -
EHF42_RS26400 46196..46444 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EHF42_RS26405 46434..46718 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHF42_RS26410 46735..46836 - 102 Protein_54 IS200/IS605 family transposase -
EHF42_RS26415 46872..48095 + 1224 WP_004181779.1 transposase -
EHF42_RS26420 48486..49673 - 1188 WP_004181780.1 transposase -
EHF42_RS26425 50339..50806 + 468 WP_124737156.1 hypothetical protein -
EHF42_RS26430 50851..51057 - 207 WP_063938351.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(3)-IIa / blaTEM-1B / blaCTX-M-15 / aph(3')-Ia / dfrA1 / blaSHV-5 / sul1 / qacE / ant(3'')-Ia iucA / iucB / iucC / iucD / iutA / rmpA 1..345775 345775


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T115059 WP_004181778.1 NZ_CP034046:46434-46718 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T115059 NZ_CP034046:46434-46718 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT115059 WP_004181777.1 NZ_CP034046:46196-46444 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT115059 NZ_CP034046:46196-46444 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCTGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References