115018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 4886274..4886836 Replicon chromosome
Accession NZ_CP034036
Organism Brenneria nigrifluens DSM 30175 = ATCC 13028

Toxin (Protein)


Gene name parE Uniprot ID G7LR73
Locus tag EH206_RS22950 Protein ID WP_009115141.1
Coordinates 4886274..4886567 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G7LR74
Locus tag EH206_RS22955 Protein ID WP_009115142.1
Coordinates 4886555..4886836 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH206_RS22930 4882428..4883759 + 1332 WP_009115138.1 putative aminohydrolase SsnA -
EH206_RS22935 4884049..4885350 + 1302 WP_040344235.1 hypothetical protein -
EH206_RS23240 4885377..4885907 - 531 WP_009115140.1 virulence RhuM family protein -
EH206_RS22945 4885977..4886213 - 237 WP_136163950.1 hypothetical protein -
EH206_RS22950 4886274..4886567 - 294 WP_009115141.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EH206_RS22955 4886555..4886836 - 282 WP_009115142.1 CopG family ribbon-helix-helix protein Antitoxin
EH206_RS22960 4887115..4888479 - 1365 WP_009115143.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
EH206_RS22965 4888557..4890194 - 1638 WP_009115144.1 membrane protein insertase YidC -
EH206_RS22970 4890197..4890454 - 258 WP_009115145.1 membrane protein insertion efficiency factor YidD -
EH206_RS22975 4890418..4890777 - 360 WP_009115146.1 ribonuclease P protein component -
EH206_RS22980 4890796..4890936 - 141 WP_009115147.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11210.98 Da        Isoelectric Point: 7.2010

>T115018 WP_009115141.1 NZ_CP034036:c4886567-4886274 [Brenneria nigrifluens DSM 30175 = ATCC 13028]
MPQVIITQRAATGLTRGREFLTNKNPLAAIKAGQVLEAHFEQLENKPEMGRPFIELPILRELMIEFGDSGYVALYRYEKI
EDRIYVLAFRHQKEAGY

Download         Length: 294 bp

>T115018 NZ_CP034036:c4886567-4886274 [Brenneria nigrifluens DSM 30175 = ATCC 13028]
ATGCCACAAGTGATCATTACTCAACGAGCGGCAACCGGATTAACTCGCGGTCGTGAGTTTCTGACCAATAAAAATCCGCT
GGCAGCTATCAAGGCCGGTCAAGTGCTCGAAGCGCATTTTGAGCAACTGGAAAACAAACCAGAAATGGGCCGCCCTTTTA
TTGAGCTGCCTATATTGCGGGAATTGATGATTGAATTCGGAGATTCCGGCTATGTGGCGTTGTACCGCTATGAGAAAATA
GAAGACCGTATTTATGTGCTGGCCTTTCGTCATCAGAAAGAAGCAGGATATTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10858.10 Da        Isoelectric Point: 5.2157

>AT115018 WP_009115142.1 NZ_CP034036:c4886836-4886555 [Brenneria nigrifluens DSM 30175 = ATCC 13028]
MSTSSTTLKIDDNLKERVKKLAASRDRSPHYLMIAAITQYIEREEARESFKQEALDSWREYQETGLHLTGDEVKTWLRGW
GTETETDIPECHK

Download         Length: 282 bp

>AT115018 NZ_CP034036:c4886836-4886555 [Brenneria nigrifluens DSM 30175 = ATCC 13028]
ATGTCAACATCAAGCACCACACTCAAAATCGACGACAACCTTAAAGAACGAGTTAAAAAACTGGCGGCTTCTCGCGATCG
TAGCCCGCATTATCTGATGATTGCCGCTATCACCCAATATATTGAACGTGAAGAGGCGCGCGAAAGCTTTAAGCAGGAAG
CGCTTGATTCCTGGCGTGAATATCAGGAAACCGGCCTGCATCTGACTGGTGATGAAGTCAAAACCTGGCTGCGTGGTTGG
GGAACAGAAACGGAAACGGACATTCCTGAATGCCACAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U1ULS1

Antitoxin

Source ID Structure
AlphaFold DB A0A2U1ULV7

References