Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4001750..4003338 Replicon chromosome
Accession NZ_CP034035
Organism Brenneria rubrifaciens strain 6D370

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EH207_RS17940 Protein ID WP_137715193.1
Coordinates 4002019..4003338 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EH207_RS17935 Protein ID WP_137715192.1
Coordinates 4001750..4002019 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH207_RS17915 3996842..3998245 + 1404 Protein_3469 PTS transporter subunit EIIC -
EH207_RS17920 3998437..3999819 + 1383 WP_137715190.1 carbohydrate porin -
EH207_RS17925 3999982..4000335 - 354 WP_137715416.1 helix-turn-helix transcriptional regulator -
EH207_RS17930 4000462..4001313 + 852 WP_137715191.1 SDR family oxidoreductase -
EH207_RS17935 4001750..4002019 + 270 WP_137715192.1 helix-turn-helix domain-containing protein Antitoxin
EH207_RS17940 4002019..4003338 + 1320 WP_137715193.1 type II toxin-antitoxin system HipA family toxin Toxin
EH207_RS17945 4004478..4005113 + 636 Protein_3475 hypothetical protein -
EH207_RS17950 4005168..4006202 + 1035 WP_137715194.1 IS630 family transposase -
EH207_RS17955 4006227..4006763 + 537 Protein_3477 hypothetical protein -
EH207_RS17960 4007349..4008212 + 864 WP_137715195.1 integrase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4005147..4006202 1055


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49432.75 Da        Isoelectric Point: 8.6594

>T114985 WP_137715193.1 NZ_CP034035:4002019-4003338 [Brenneria rubrifaciens]
MAALDVYMNGYRVGVFTKTSSGAHRFSYDENWLGLSGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNLDIRRRIVARHH
ADSTQPFDLLAKVGQDSVGALQLVQQGTPVHDIKRIEYKTLSEQQFERILSGYQSDAPLGMIDAEDDFRISIAGAQEKTA
LLYLDDHWRLPLNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCMLIAKAFGLPVPHCFMIKAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQALNIPSARKYENHGGPGICAIMSVLLGAVDPERDRYSFMKAQVLFWLLAATDGHAKNFSLFI
ESQGRYRLTPYYDILSMYPAIGGRGIDRRDAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILAEFAQSM
DAVVVKIRNQLPAGFPAPIRDAILNGMQAKARRLTIGWN

Download         Length: 1320 bp

>T114985 NZ_CP034035:4002019-4003338 [Brenneria rubrifaciens]
ATGGCTGCGCTTGATGTTTACATGAACGGCTATCGGGTGGGCGTTTTTACCAAAACAAGCAGTGGCGCGCATCGTTTTTC
CTATGATGAGAACTGGCTTGGACTATCAGGTAGTCGCCCCATCTCGCTCTCTATGCCGCTACGCCATCAGCCCTATCAAG
GTGATGAAGTTTATAACTTCTTCGACAATTTACTGCCGGATAATCTGGATATCAGAAGACGCATTGTCGCCAGACATCAC
GCAGATTCCACCCAGCCGTTTGATCTGCTGGCTAAAGTGGGGCAAGACAGCGTCGGGGCGTTACAATTGGTGCAGCAGGG
TACGCCTGTTCACGATATAAAACGGATCGAATACAAAACCTTATCCGAGCAACAATTTGAACGCATATTGAGTGGATATC
AGTCGGATGCCCCGCTCGGGATGATCGACGCAGAAGACGATTTTCGTATCTCCATCGCTGGCGCACAGGAAAAGACGGCG
CTGCTCTATCTGGATGACCACTGGCGTCTGCCCCTTAATGCCACGCCAACCACCCACATCATCAAGCTGCCGATTGGTAA
AATCGAGAGTCACTCTTACTCGATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGCATGCTCATTGCCAAGGCGT
TTGGGCTACCGGTGCCGCACTGTTTTATGATCAAAGCGGGCAAGATAAAAGCGCTGGCGGTAGAACGTTTTGATCGCAAA
TATGCCTCGGATGGCCGTTGGATTATGCGGTTGCCGCAAGAGGATTTTTGCCAGGCATTAAATATTCCTTCCGCACGAAA
ATACGAAAACCATGGTGGACCTGGCATTTGCGCCATTATGTCGGTTCTATTGGGCGCGGTTGATCCAGAAAGGGATCGTT
ATAGCTTTATGAAGGCTCAGGTACTATTTTGGCTATTGGCCGCAACGGATGGGCATGCGAAAAACTTTTCCTTATTTATT
GAATCGCAAGGACGATATCGTCTCACGCCTTACTATGACATTCTCTCTATGTACCCGGCGATTGGCGGTCGGGGAATTGA
CCGCAGAGATGCCAAACTTGCGATGGGACTGACCGGCTCAAGAGGCAAGAAATACGCTATTGAGCAGATCTTTCCACGGC
ACTTTTTCCAAACGGCGAAGGCGGTTGGGTTTGCCAGAGAATCGATGGAAAACATTTTGGCTGAGTTTGCGCAGTCGATG
GACGCTGTTGTTGTGAAAATAAGAAACCAACTGCCCGCTGGTTTTCCTGCGCCTATCCGCGATGCTATTTTGAATGGAAT
GCAGGCGAAAGCGAGGCGGTTAACTATCGGGTGGAATTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9884.15 Da        Isoelectric Point: 9.7281

>AT114985 WP_137715192.1 NZ_CP034035:4001750-4002019 [Brenneria rubrifaciens]
MKVTNTKQLSAYLKDVRITQKLSQGKVAGKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNADAANNEASV
ASSSWKEEW

Download         Length: 270 bp

>AT114985 NZ_CP034035:4001750-4002019 [Brenneria rubrifaciens]
ATGAAAGTCACCAACACCAAACAGCTTAGCGCCTATCTGAAAGATGTCCGCATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCGGTAAAGTGGGTATTCGCCAGGATACGGTATCCAGCTTCGAGCAACATCCTGATTCCACCAAGCTGGAAACCTTCT
TTAAAATCCTGTCGGCATTAAATTTAGAACTGACTGTTACTCCCAGGAATGCGGATGCAGCCAATAATGAAGCTTCTGTT
GCATCATCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References