Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 431463..431989 Replicon chromosome
Accession NZ_CP034035
Organism Brenneria rubrifaciens strain 6D370

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag EH207_RS02005 Protein ID WP_121574721.1
Coordinates 431463..431768 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag EH207_RS02010 Protein ID WP_121574722.1
Coordinates 431771..431989 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH207_RS01990 427724..428074 + 351 WP_137712511.1 hypothetical protein -
EH207_RS01995 428096..429892 - 1797 WP_137712512.1 hypothetical protein -
EH207_RS02005 431463..431768 - 306 WP_121574721.1 type II toxin-antitoxin system toxin CcdB Toxin
EH207_RS02010 431771..431989 - 219 WP_121574722.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
EH207_RS02015 432230..432511 - 282 WP_137712514.1 helix-turn-helix domain-containing protein -
EH207_RS02020 432660..432974 + 315 WP_137712515.1 helix-turn-helix domain-containing protein -
EH207_RS02025 433161..433475 + 315 WP_137712516.1 helix-turn-helix domain-containing protein -
EH207_RS02030 434076..434333 + 258 WP_121588677.1 antitoxin -
EH207_RS02035 434334..434666 + 333 WP_137712517.1 type II toxin-antitoxin system PemK/MazF family toxin -
EH207_RS02045 435475..436356 + 882 WP_137712518.1 integrase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - htpB 414739..459030 44291


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11858.76 Da        Isoelectric Point: 6.2242

>T114981 WP_121574721.1 NZ_CP034035:c431768-431463 [Brenneria rubrifaciens]
MQFIVYQYKRVSHYKMFVDVQSDIVDTPKRRMVIPLIESHHMSEKVNKTLFPRLRINGENYRLMTTELSSVSVEVMGETI
ADLGEYADEIKDAINLMFWGI

Download         Length: 306 bp

>T114981 NZ_CP034035:c431768-431463 [Brenneria rubrifaciens]
ATGCAATTCATTGTTTACCAATACAAACGCGTCAGTCATTACAAAATGTTTGTTGATGTGCAAAGTGATATTGTCGATAC
ACCAAAACGGCGCATGGTCATTCCGCTTATCGAATCGCATCACATGTCTGAGAAAGTGAATAAGACACTGTTCCCTCGAC
TCCGCATCAACGGCGAAAATTATCGGCTGATGACCACTGAACTATCAAGCGTTTCCGTTGAAGTCATGGGTGAAACTATC
GCGGATCTTGGCGAGTATGCCGATGAGATTAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8222.18 Da        Isoelectric Point: 7.0135

>AT114981 WP_121574722.1 NZ_CP034035:c431989-431771 [Brenneria rubrifaciens]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDVIGKEARRIKAEEWKKENREGMEEVARFIAQNGSFSDENRNW

Download         Length: 219 bp

>AT114981 NZ_CP034035:c431989-431771 [Brenneria rubrifaciens]
ATGAAACACCGCGTTAGCGTTACCGTGGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAGTCAACATTTCTGGTCT
GGTAAATGACGTCATTGGCAAGGAAGCCCGCCGTATAAAGGCTGAGGAATGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCAGATTTATCGCACAGAATGGTTCCTTTTCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References