Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1637404..1638089 | Replicon | chromosome |
| Accession | NZ_CP034032 | ||
| Organism | Neisseria gonorrhoeae strain FQ01 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | EGH16_RS09570 | Protein ID | WP_003689143.1 |
| Coordinates | 1637907..1638089 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | EGH16_RS09565 | Protein ID | WP_003691454.1 |
| Coordinates | 1637404..1637805 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EGH16_RS09515 | 1632882..1633097 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| EGH16_RS09520 | 1633149..1633640 | - | 492 | WP_004464807.1 | siphovirus Gp157 family protein | - |
| EGH16_RS09525 | 1633637..1633819 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| EGH16_RS09530 | 1633959..1634645 | - | 687 | WP_010357532.1 | hypothetical protein | - |
| EGH16_RS09535 | 1634714..1634875 | - | 162 | WP_047924242.1 | hypothetical protein | - |
| EGH16_RS09540 | 1634872..1635147 | - | 276 | WP_003705605.1 | hypothetical protein | - |
| EGH16_RS09545 | 1635300..1635632 | - | 333 | WP_003695500.1 | hypothetical protein | - |
| EGH16_RS09550 | 1635771..1635971 | - | 201 | WP_003695499.1 | hypothetical protein | - |
| EGH16_RS09555 | 1636212..1636628 | - | 417 | WP_003693479.1 | hypothetical protein | - |
| EGH16_RS09560 | 1636637..1637221 | - | 585 | WP_003693477.1 | SocA family protein | - |
| EGH16_RS09565 | 1637404..1637805 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| EGH16_RS09570 | 1637907..1638089 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| EGH16_RS09575 | 1638259..1639077 | - | 819 | WP_047949659.1 | DUF3037 domain-containing protein | - |
| EGH16_RS09580 | 1639350..1640105 | - | 756 | WP_003693472.1 | LexA family transcriptional regulator | - |
| EGH16_RS09585 | 1640242..1640427 | + | 186 | WP_002238713.1 | Cro/Cl family transcriptional regulator | - |
| EGH16_RS09590 | 1640516..1640671 | + | 156 | WP_003691446.1 | hypothetical protein | - |
| EGH16_RS09595 | 1640648..1640836 | - | 189 | WP_003696008.1 | hypothetical protein | - |
| EGH16_RS09600 | 1641009..1641236 | + | 228 | WP_003691442.1 | helix-turn-helix domain-containing protein | - |
| EGH16_RS09605 | 1641233..1642198 | + | 966 | WP_124743213.1 | helix-turn-helix domain-containing protein | - |
| EGH16_RS09610 | 1642210..1642989 | + | 780 | WP_025455804.1 | ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1622654..1654909 | 32255 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T114978 WP_003689143.1 NZ_CP034032:c1638089-1637907 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T114978 NZ_CP034032:c1638089-1637907 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT114978 WP_003691454.1 NZ_CP034032:c1637805-1637404 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT114978 NZ_CP034032:c1637805-1637404 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATTCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATTCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|