Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1596385..1597070 | Replicon | chromosome |
| Accession | NZ_CP034030 | ||
| Organism | Neisseria gonorrhoeae strain FQ02 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | EGH17_RS09430 | Protein ID | WP_003689143.1 |
| Coordinates | 1596888..1597070 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | EGH17_RS09425 | Protein ID | WP_003691454.1 |
| Coordinates | 1596385..1596786 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EGH17_RS09370 | 1591407..1591622 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| EGH17_RS09375 | 1591674..1592165 | - | 492 | WP_047918703.1 | siphovirus Gp157 family protein | - |
| EGH17_RS09380 | 1592162..1592344 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| EGH17_RS09385 | 1592484..1593170 | - | 687 | WP_033910330.1 | hypothetical protein | - |
| EGH17_RS09390 | 1593239..1593400 | - | 162 | WP_003691530.1 | hypothetical protein | - |
| EGH17_RS09395 | 1593397..1593672 | - | 276 | WP_047923918.1 | hypothetical protein | - |
| EGH17_RS09400 | 1593826..1594158 | - | 333 | WP_047923919.1 | hypothetical protein | - |
| EGH17_RS09405 | 1594299..1594598 | - | 300 | WP_124728932.1 | hypothetical protein | - |
| EGH17_RS09410 | 1594595..1595071 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| EGH17_RS09415 | 1595104..1595304 | - | 201 | WP_047917349.1 | hypothetical protein | - |
| EGH17_RS09420 | 1595504..1596286 | + | 783 | WP_003689146.1 | hypothetical protein | - |
| EGH17_RS09425 | 1596385..1596786 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| EGH17_RS09430 | 1596888..1597070 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| EGH17_RS09435 | 1597240..1598058 | - | 819 | WP_012503752.1 | DUF3037 domain-containing protein | - |
| EGH17_RS09440 | 1598055..1598753 | - | 699 | WP_048654307.1 | hypothetical protein | - |
| EGH17_RS09445 | 1598992..1599690 | - | 699 | WP_002212401.1 | helix-turn-helix domain-containing protein | - |
| EGH17_RS09450 | 1599730..1600383 | - | 654 | WP_157149898.1 | helix-turn-helix transcriptional regulator | - |
| EGH17_RS09455 | 1600581..1600766 | + | 186 | WP_048654326.1 | helix-turn-helix domain-containing protein | - |
| EGH17_RS13660 | 1600768..1600968 | + | 201 | WP_012503750.1 | hypothetical protein | - |
| EGH17_RS09465 | 1601165..1601971 | + | 807 | WP_050154472.1 | replication protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1581178..1614850 | 33672 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T114976 WP_003689143.1 NZ_CP034030:c1597070-1596888 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T114976 NZ_CP034030:c1597070-1596888 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT114976 WP_003691454.1 NZ_CP034030:c1596786-1596385 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT114976 NZ_CP034030:c1596786-1596385 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|